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2018
Among various biological data, DNA sequence is doubtlessly a fundamental datum. By obtaining particular DNA sequence data and analyzing, biologists get to understand life science more precisely. This chapter is an overview of DNA sequencing technology and its data analysis methods, providing information about DNA sequencing, several different methods ...
Keyi, Long, Lei, Cai, Lin, He
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Among various biological data, DNA sequence is doubtlessly a fundamental datum. By obtaining particular DNA sequence data and analyzing, biologists get to understand life science more precisely. This chapter is an overview of DNA sequencing technology and its data analysis methods, providing information about DNA sequencing, several different methods ...
Keyi, Long, Lei, Cai, Lin, He
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Statistical Methods in Medical Research, 1993
Recent developments in the statistical analysis of DNA sequences are reviewed. The pace with which sequence data are being generated and analysed has increased with the growth of the human genome project. Two areas of activity are emphasized: attention to error rates in recorded sequences, and heterogeneity in structure of sequences.
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Recent developments in the statistical analysis of DNA sequences are reviewed. The pace with which sequence data are being generated and analysed has increased with the growth of the human genome project. Two areas of activity are emphasized: attention to error rates in recorded sequences, and heterogeneity in structure of sequences.
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Nucleotide sequence analysis of DNA
Journal of Molecular Biology, 1970There are three major obstacles to the analysis of the nucleotide sequence in a DNA molecule starting from a known location in the DNA molecule. First, it is difficult to obtain large quantities of homogeneous DNA. Second, even the smallest DNA molecules contain several thousand nucleotides which make sequence analysis prohibitive.
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Quantitative SERRS for DNA sequence analysis
Chemical Society Reviews, 2008SERRS is an extremely sensitive and selective technique which when applied to the detection of labelled DNA sequences allows detection limits to be obtained which rival, and in most cases are better than, fluorescence. In this tutorial review the conditions are explored which enable the successful detection of DNA using SERRS.
Graham, Duncan, Faulds, Karen
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Mitochondrial DNA sequence analysis in Sicily
American Journal of Human Biology, 2001AbstractThis study reports data on the sequences of the first hypervariable segment of a sample of the Sicilian population from Alia (Palermo, Italy). The results show the presence of 32 different haplotypes in the 49 individuals examined. The average number of pairwise nucleotide differences was 4.04, i.e., 1.17% per nucleotide.
Vona G +5 more
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Recent Advances in DNA Sequence Analysi
CRC Critical Reviews in Biochemistry, 1975(1975). Recent Advances in DNA Sequence Analysi. CRC Critical Reviews in Biochemistry: Vol. 2, No. 4, pp. 455-512.
Ray Wu +3 more
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Statistical Analysis of DNA Sequences
JNCI Journal of the National Cancer Institute, 1988Developments in the statistical analysis of DNA sequence data since 1984 are reviewed. Mathematical methods employing dynamic programming or incorporating Markov chain theory have been developed to search sequences for regions of similarity and to align sequences.
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Computer support of DNA sequence analysis
Computer Programs in Biomedicine, 1981The paper describes a package of APL-programs suited for the management and the analysis of DNA sequence data. Most of the application programs are related to experimental work in a DNA sequencing laboratory: Search for overlapping DNA fragments to construct complete DNA sequences; search for restriction sites; computing fragment patterns when cutting ...
G, Osterburg, R, Sommer
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Quantitative analysis of DNA-sequencing electrophoresis
Genetic Analysis: Biomolecular Engineering, 1992At the heart of the DNA-sequencing process is a remarkably selective electrophoretic separation of up to 1000 oligonucleotide fragments, each differing in size by only a single nucleotide unit. A quantitative analysis of this separation is performed in terms of both selectivity and efficiency.
P D, Grossman, S, Menchen, D, Hershey
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Video analysis of DNA sequence homologs
Analytical Chemistry, 1992A method for the rapid quantitative analysis of dot blot assays is presented. A video camera, an NTSC compatible frame grabber board, and an AT personal computer are used to read photographic exposures of the assay plate. Image processing and image analysis techniques are used to calculate the orientation of the dot raster and then to compensate for ...
M, Ludwig, R J, Hartzman
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