Results 51 to 60 of about 2,821,158 (289)

Understanding the sequence-dependence of DNA groove dimensions: implications for DNA interactions. [PDF]

PLoS ONE, 2010
BACKGROUND: The B-DNA major and minor groove dimensions are crucial for DNA-protein interactions. It has long been thought that the groove dimensions depend on the DNA sequence, however this relationship has remained elusive.
Christophe Oguey, Nicolas Foloppe, Brigitte Hartmann   +2 more
doaj   +1 more source

Comparative DNA sequence analysis of wheat and rice genomes.

Genome Research, 2003
The use of DNA sequence-based comparative genomics for evolutionary studies and for transferring information from model species to crop species has revolutionized molecular genetics and crop improvement strategies.
M. Sorrells, Mauricio La Rota, C. E. Bermudez-Kandianis, R. A. Greene, R. Kantety, J. Munkvold, Miftahudin, A. Mahmoud, Xuefeng Ma, P. Gustafson, L. Qi, Benjamin Echalier, B. Gill, D. Matthews, G. Lazo, S. Chao, O. Anderson, H. Edwards, A. Linkiewicz, J. Dubcovsky, E. Akhunov, J. Dvorak, Deshui Zhang, H. Nguyen, Junhua Peng, N. Lapitan, J. Gonzalez-Hernandez, J. Anderson, Khwaja G. Hossain, V. Kalavacharla, S. Kianian, D. Choi, T. Close, M. Dilbirliği, K. Gill, C. Steber, M. Walker-Simmons, P. McGuire, C. Qualset   +38 more
semanticscholar   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

DNA sequence analysis landscape: a comprehensive review of DNA sequence analysis task types, databases, datasets, word embedding methods, and language models

Frontiers in Medicine
Deoxyribonucleic acid (DNA) serves as fundamental genetic blueprint that governs development, functioning, growth, and reproduction of all living organisms. DNA can be altered through germline and somatic mutations. Germline mutations underlie hereditary
Muhammad Nabeel Asim, Muhammad Nabeel Asim, Muhammad Ali Ibrahim, Muhammad Ali Ibrahim, Arooj Zaib, Andreas Dengel, Andreas Dengel, Andreas Dengel   +7 more
doaj   +1 more source

Primary structure of rat cardiac beta-adrenergic and muscarinic cholinergic receptors obtained by automated DNA sequence analysis: further evidence for a multigene family.

Proceedings of the National Academy of Sciences of the United States of America, 1987
Two cDNA clones, lambda RHM-MF and lambda RHB-DAR, encoding the muscarinic cholinergic receptor and the beta-adrenergic receptor, respectively, have been isolated from a rat heart cDNA library.
J. Gocayne, D. Robinson, M. FitzGerald, F. Chung, A. Kerlavage, K. Lentes, J. Lai, Cheng-Dian Wang, C. Fraser, J. Venter   +9 more
semanticscholar   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

THE DNA SEQUENCE ENCODING GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE (GAPC) ENZYME ON TUNTUN ANGIN PLANT (ELAEOCARPUS FLORIBUNDUS BI)

BioLink, 2020
Glyceraldehyde 3-phosphate dehydrogenase (GapC) is an enzyme involved in glycolysis. The expression of this gene tends to abundant in eukaryotic cells, so this gene is frequently used as an internal control in gene expression analysis. This research aims
Dewi Indriyani Roslim, Hestia Hairima, Herman Herman, Wahyu Lestari   +3 more
doaj   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

A sequence-based 163plex microhaplotype assay for forensic DNA analysis

Frontiers in Genetics, 2022
Novel genetic marker microhaplotype has led to an upsurge in forensic genetic research. This study established a 163 microhaplotype (MH) multiplex assay based on next-generation sequencing (NGS) and evaluated the assay’s performance and applicability ...
Ruiyang Tao, Qi Yang, Ruocheng Xia, Xiaochun Zhang, Anqi Chen, Chengtao Li, Suhua Zhang   +6 more
doaj   +1 more source

"Nonrandom" DNA sequence analysis in bacteriophage M13 by the dideoxy chain-termination method.

Proceedings of the National Academy of Sciences of the United States of America, 1982
We describe a rapid "nonrandom" DNA sequence analysis procedure that facilitates the nucleotide sequence determination of large contiguous regions of DNA.
M. Poncz, D. Solowiejczyk, M. Ballantine, E. Schwartz, S. Surrey   +4 more
semanticscholar   +1 more source