Results 91 to 100 of about 3,346,579 (352)

In vivo analysis of NHPX reveals a novel nucleolar localization pathway involving a transient accumulation in splicing speckles [PDF]

, 2002
The NHPX protein is a nucleolar factor that binds directly to a conserved RNA target sequence found in nucleolar box C/D snoRNAs and in U4 snRNA. Using enhanced yellow fluorescent protein (EYFP)– and enhanced cyan fluorescent protein–NHPX fusions, we ...
Lamond, Angus I., Leung, Anthony K. L.
core   +4 more sources

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Non‐Coding RNA Analysis Using the Rfam Database

Current Protocols in Bioinformatics, 2018
Rfam is a database of non‐coding RNA families in which each family is represented by a multiple sequence alignment, a consensus secondary structure, and a covariance model. Using a combination of manual and literature‐based curation and a custom software
Ioanna Kalvari, Eric P. Nawrocki, Joanna Argasinska, Natalia Quinones-Olvera, R. Finn, A. Bateman, Anton I. Petrov   +6 more
semanticscholar   +1 more source

PhylOTU: a high-throughput procedure quantifies microbial community diversity and resolves novel taxa from metagenomic data. [PDF]

, 2011
Microbial diversity is typically characterized by clustering ribosomal RNA (SSU-rRNA) sequences into operational taxonomic units (OTUs). Targeted sequencing of environmental SSU-rRNA markers via PCR may fail to detect OTUs due to biases in priming and ...
Eisen, Jonathan A, Green, Jessica L, Kembel, Steven W, Ladau, Joshua, O'Dwyer, James P, Pollard, Katherine S, Riesenfeld, Samantha J, Sharpton, Thomas J   +7 more
core   +3 more sources

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

PRADA: pipeline for RNA sequencing data analysis [PDF]

Bioinformatics, 2014
Abstract Summary:  Technological advances in high-throughput sequencing necessitate improved computational tools for processing and analyzing large-scale datasets in a systematic automated manner. For that purpose, we have developed PRADA (Pipeline for RNA-Sequencing Data Analysis), a flexible, modular and highly scalable software ...
Rahulsimham Vegesna, Qianghu Wang, Rong Yao, John N. Weinstein, Wandaliz Torres-Garcia, Andrey Sivachenko, Roel G.W. Verhaak, Siyuan Zheng, Gad Getz, Michael F. Berger   +9 more
openaire   +3 more sources

RNA-seq data science: From raw data to effective interpretation [PDF]

arXiv, 2020
RNA-sequencing (RNA-seq) has become an exemplar technology in modern biology and clinical applications over the past decade. It has gained immense popularity in the recent years driven by continuous efforts of the bioinformatics community to develop accurate and scalable computational tools.
arxiv  

Nucleotide Sequence Analysis of RNA-3 and RNA-4 of Beet Necrotic Yellow Vein Virus, Isolates F2 and G1

, 1985
Summary The nucleotide sequences of cDNA clones corresponding to RNA-3 and RNA-4 of beet necrotic yellow vein virus isolates F2 and G1 have been determined.
S. Bouzoubaa, H. Guilley, G. Jonard, K. Richards, C. Putz   +4 more
semanticscholar   +1 more source

The use of nuclease P1 in sequence analysis of end group labeled RNA.

Nucleic Acids Research, 1977
A method is described for the direct sequence analysis of 20-25 nucleotides from the termini of 5'- or 3'-end-group [32P] labeled RNA. The method involves partial endonucleolytic digestion of the labeled RNA with nuclease P1 (from Penicillium citrinum ...
M. Silberklang, A. M. Gillum, U. RajBhandary   +2 more
semanticscholar   +1 more source

Heterogeneity of gene expression of the hemagglutinin-esterase (HE) protein of murine coronaviruses. [PDF]

, 1991
The hemagglutinin-esterase (HE) membrane glycoprotein is present only in some members of the coronavirus family, including some strains of mouse hepatitis virus (MHV). In the JHM strain of MHV, expression of the HE gene is variable and corresponds to the
Banner, LR, Lai, MM, Yokomori, K
core