Results 111 to 120 of about 3,346,579 (352)

3D RNA and functional interactions from evolutionary couplings [PDF]

arXiv, 2015
Non-coding RNAs are ubiquitous, but the discovery of new RNA gene sequences far outpaces research on their structure and functional interactions. We mine the evolutionary sequence record to derive precise information about function and structure of RNAs and RNA-protein complexes.
arxiv  

Identifying RNA contacts from SHAPE-MaP by partial correlation analysis [PDF]

, 2014
In a recent paper Siegfried et al. published a new sequence-based structural RNA assay that utilizes mutational profiling to detect base pairing (MaP).
Doudna, Jennifer, Pachter, Lior, Tambe, Akshay   +2 more
core   +3 more sources

Three-dimensional modeling of single stranded DNA hairpins for aptamer-based biosensors. [PDF]

, 2017
Aptamers consist of short oligonucleotides that bind specific targets. They provide advantages over antibodies, including robustness, low cost, and reusability.
Jeddi, Iman, Saiz, Leonor
core   +2 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

GEE: An Informatics Tool for Gene Expression Data Explore [PDF]

Healthcare Informatics Research, 2016
ObjectivesMajor public high-throughput functional genomic data repositories, including the Gene Expression Omnibus (GEO) and ArrayExpress have rapidly expanded.
Soo Youn Lee, Chan Hee Park, Jun Hee Yoon, Sunmin Yun, Ju Han Kim   +4 more
doaj   +1 more source

RNA secondary structures having a compatible sequence of certain nucleotide ratios [PDF]

arXiv, 2016
Given a random RNA secondary structure, $S$, we study RNA sequences having fixed ratios of nuclotides that are compatible with $S$. We perform this analysis for RNA secondary structures subject to various base pairing rules and minimum arc- and stack-length restrictions.
arxiv  

Nucleotide sequence analysis of Triatoma virus shows that it is a member of a novel group of insect RNA viruses.

Journal of General Virology, 2000
Triatoma virus (TrV) is the only virus described to date that infects triatomines, and has previously been considered to be a member of the family Picornaviridae on the basis of physico-chemical properties.
C. Czibener, J. Torre, O. Muscio, R. Ugalde, E. Scodeller   +4 more
semanticscholar   +1 more source

The Reverse Transcription Signature of N-\u3csub\u3e1\u3c/sub\u3e-Methyladenosine in RNA-Seq is Sequence Dependent [PDF]

, 2015
The combination of Reverse Transcription (RT) and high-throughput sequencing has emerged as a powerful combination to detect modified nucleotides in RNA via analysis of either abortive RT-products or of the incorporation of mismatched dNTPs into cDNA ...
Alfonzo, Juan, Anderson, James T., Entian, Karl-dieter, Hauenschild, Ralf, Helm, Mark, Hildebrandt, Andreas, Jaschke, Andres, Lafontaine, Denis L.J., Motorin, Yuri, Schmid, Katharina, Sharma, Sunny, Thuring, Kathrin, Tserovski, Lyudmil, Wacheul, Ludvine, Winz, Marie-Luise   +14 more
core   +1 more source

Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. [PDF]

, 2019
BACKGROUND:The Human Epidermal Growth Factor Receptor (EGFR/HER1) can be activated by several ligands including Transforming Growth Factor alpha (TGF-α) and Epidermal Growth Factor (EGF).
Dutta, Pranabananda, Farias-Eisner, Robin, Nava, Miguel, Vadgama, Jaydutt V, Wu, Yanyuan, Zemke, Nathan R   +5 more
core   +5 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source