Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink+6 more
wiley +1 more source
Non-Linear Dynamics Analysis of Protein Sequences. Application to CYP450
The nature of changes involved in crossed-sequence scale and inner-sequence scale is very challenging in protein biology. This study is a new attempt to assess with a phenomenological approach the non-stationary and nonlinear fluctuation of changes ...
Xavier F. Cadet+3 more
doaj +1 more source
Nucleotide sequence analysis with polynucleotide kinase and nucleotide ‘mapping’ methods. 5′-Terminal sequence of deoxyribonucleic acid from bacteriophages λ and 424 [PDF]
Kenneth Murray
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Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi+3 more
wiley +1 more source
Sequence Analysis of Eukaryotic mRNA
Publisher Summary This chapter reviews that the determination of sequences in eukaryotic messenger RNAs has been revolutionized by the discovery of reverse transcriptase in RNA tumor viruses and as an inherent activity of DNA polymerase I of Escherichia coli.
Proudfoot, N, Cheng, C, Brownlee, G
openaire +4 more sources
DNA sequence analysis: a formula to predict electrophoretic mobilities of oligonucleotides on cellulose acetate [PDF]
Robert A. Bambara, Ernest Jay, Ray Wü
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Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker+14 more
wiley +1 more source
Sequence analysis of 5′[32P labeled mRNA and tRNA using polyacrylamide gel electrophoresis [PDF]
Raymond E. Lockard+5 more
openalex +1 more source
Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha+6 more
wiley +1 more source
Growth and financial reforms trajectory: an optimal matching sequence analysis approach [PDF]
This paper makes two important , even if preliminary, methodological contributions to the financial reforms literature. The first contribution is that it introduces a new framework for the metric of sequence analysis, namely, Optimal Matching Sequence ...
Bicaba, Zorobabel
core +1 more source