Results 101 to 110 of about 152,864 (305)

Separating arterial pressure increases and decreases in assessing cardiac baroreflex sensitivity via sequence and bivariate phase rectified signal averaging techniques

, 2018
Cardiac baroreflex (cBR) is activated by both arterial pressure (AP) increases and decreases. Sequence method, a widely utilized tool assessing cBR sensitivity (cBRS) from spontaneous heart period (HP) and systolic AP (SAP) variations, allows the ...
G. Ranuzzi, V. Pistuddi, A. M. Catai, M. Ranucci, S. Cerutti, V. Bari, L. Dalla Vecchia, B. De Maria, A. C. M. Takahashi, A. Porta   +9 more
core   +1 more source

Coded excitation speeds up the detection of the fundamental flexural guided wave in coated tubes

AIP Advances, 2016
The fundamental flexural guided wave (FFGW) permits ultrasonic assessment of the wall thickness of solid waveguides, such as tubes or, e.g., long cortical bones. Recently, an optical non-contact method was proposed for ultrasound excitation and detection
Xiaojun Song, Petro Moilanen, Zuomin Zhao, Dean Ta, Jalmari Pirhonen, Ari Salmi, Edward Hæeggström, Risto Myllylä, Jussi Timonen, Weiqi Wang   +9 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Phase averaging in one-dimensional random systems

, 1982
We calculate the resistance of a random sequence of scatterers and show that, in general, the phase uncertainty does not increase with the length of the wire.
Thorpe, M. F., Lambert, Colin
core  

Estimates of evolutionary divergence over sequence pairs between clades.

, 2019
The number of base substitutions per site from averaging over all sequence pairs between groups are shown. Standard error estimate(s) are shown above the diagonal.
Tomasz Strzała (563229), Ewa Filip (6407642), Izabela Szućko (6407639), Lidia Skuza (6407636)   +3 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Selective Averaging of Cognitive Evoked Potentials

, 2007
This work is about the development of an alternative way of averaging evoked potentials (EP) of cognitive activities. Since the main assumption of invariant waveforms time locked to the elicting events does not hold for cognitive EPs, averaging results ...
Arthur Flexer, Herbert Bauer
core  

Estimates of average evolutionary divergence over sequence pairs within clades.

, 2019
The number of base substitutions per site from averaging over all sequence pairs within each group are shown (MPD) along with standard error estimate(s) (SE).
Tomasz Strzała (563229), Ewa Filip (6407642), Izabela Szućko (6407639), Lidia Skuza (6407636)   +3 more
core   +1 more source