Results 111 to 120 of about 152,864 (305)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Genetic marker data for sweetpotato improvementDataverse

Data in Brief
A total of 768 molecular markers were developed for Ipomoea batatas (L.) Lam., consisting of 689 simple sequence repeats (SSRs) and 79 single nucleotide polymorphisms (SNPs).
Imana L. Power, Brian E. Scheffler, Xiaofen F. Liu, Sheron A. Simpson, Linda L. Ballard, Marshall C. Lamb, Renee S. Arias   +6 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Multiple Sequence Alignment Averaging Improves Phylogeny Reconstruction

, 2018
The classic methodology of inferring a phylogenetic tree from sequence data is composed of two steps. First, a multiple sequence alignment (MSA) is computed. Then, a tree is reconstructed assuming the MSA is correct.
Itamar Sela, Haim Ashkenazy, Eli Levy Karin, Tal Pupko, Giddy Landan   +4 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Proportions of unique and cosmopolitan OTU between oceanic regions and individual samples at the class (a, b) and OTU_0.03 (c, d) level, after averaging of 100 sequence random resampling results (n sequences = 6883, standard deviations are indicated).

, 2016
Proportions of unique and cosmopolitan OTU between oceanic regions and individual samples at the class (a, b) and OTU0.03 (c, d) level, after averaging of 100 sequence random resampling results (n sequences = 6883, standard deviations are indicated).
Christina Bienhold (107582), Antje Boetius (58870), Alban Ramette (37315), Lucie Zinger (206567)   +3 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Annealing Between Distributions by Averaging Moments

, 2014
Many powerful Monte Carlo techniques for estimating partition functions, such as annealed importance sampling (AIS), are based on sampling from a sequence of intermediate distributions which interpolate between a tractable initial distribution and the ...
Salakhutdinov, Russ
core  

Reduction of Motion Artifacts in Magnetic Resonance Imaging of the Neck and Cervical Spine by Long-Term Averaging

, 2000
RATIONALE AND OBJECTIVES. We performed a prospective comparison of T1-weighted turbo spin-echo (TSE) imaging with standard averaging and with the long-term averaging method (LOTA), comparing the effects on signal-to-artifact noise ratio (S/aN) and motion
NITZ, WOLFGANG R., VÖLK, MARKUS, SEITZ, JOHANNES, STROTZER, MICHAEL, HELD, PAUL, DJAVIDANI, BEHRUS, FEUERBACH, STEFAN   +6 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source