Results 101 to 110 of about 1,274,222 (313)
Protocol for constructing glycan biosynthetic networks using glycowork
STAR ProtocolsSummary: Glycans, present across all domains of life, comprise a wide range of monosaccharides assembled into complex, branching structures. Here, we present an in silico protocol to construct biosynthetic networks from a list of observed glycans using ...
Jon Lundstrøm +2 more
doaj +1 more source
Guest Editorial: Computational Biology
, 2014 Computational biology has been used to help sequence the human genome, create accurate models of the human brain, and assist in modeling biological systems. With the availability of massive datasets, it has also become possible to study different systems
Gupta, Pushpendra K; Ch. Charan Singh University Meerut, UP India
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Protocol for genetic load analysis in caribou using a modified genomic evolutionary rate profiling
STAR ProtocolsSummary: Here, we present a protocol to analyze genetic load in caribou (Rangifer tarandus) using a modified version of the genomic evolutionary rate profiling (GERP) program.
Rebecca S. Taylor +3 more
doaj +1 more source
AlphaFold-multimer predicts ATG8 protein binding motifs crucial for autophagy research
PLoS Biology, 2023 In this issue of PLOS Biology, Ibrahim and colleagues demonstrate how AlphaFold-multimer, an artificial intelligence–based structure prediction tool, can be used to identify sequence motifs binding to the ATG8 family of proteins central to autophagy ...
Hallvard Lauritz Olsvik, Terje Johansen
doaj
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Epstein-Barr Virus Sequence Variation—Biology and Disease
Pathogens, 2012 Some key questions in Epstein-Barr virus (EBV) biology center on whether naturally occurring sequence differences in the virus affect infection or EBV associated diseases. Understanding the pattern of EBV sequence variation is also important for possible
Stelios Tzellos, Paul J. Farrell
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Structural biology of telomeres and telomerase
Cellular and Molecular Life Sciences, 2019 Telomeres are protein–DNA complexes that protect chromosome ends from illicit ligation and resection. Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA to counter telomere shortening.
E. Smith, D. Pendlebury, J. Nandakumar
semanticscholar +1 more source
Guide for phenotype-specific profiling of DNA G-quadruplex-regulated genes
STAR ProtocolsSummary: DNA G-quadruplex (G4) is a non-canonical four-stranded secondary structure that has been shown to play a role in epigenetic modulation of gene expression.
Zhuoyang Zhao +3 more
doaj +1 more source