Results 101 to 110 of about 4,078,643 (261)

Multilocus sequence typing as a replacement for serotyping in Salmonella enterica [PDF]

, 2012
Salmonella enterica subspecies enterica is traditionally subdivided into serovars by serological and nutritional characteristics. We used Multilocus Sequence Typing (MLST) to assign 4,257 isolates from 554 serovars to 1092 sequence types (STs).
Uesbeck, Alexandra, Hales, James, Satheesh Nair, Wain John, Krauland, Mary G., Harbottle Heather, Mary G. Krauland (157219), Zhou, Z, Hale, JL, Brisse Sylvain, Brisse, S., Nair, S, Alexandra Uesbeck (157229), Zhou Zhemin, Brisse, Sylvain, Harbottle, Heather, John Wain (157211), Weill, FX, Zhou, Z., Weill, François-Xavier, Zhemin Zhou (157214), Heather Harbottle (157226), Vartul Sangal, The S.enterica MLST study group, Gordon Dougan, Hale James L., Hale, J.L., Sangal, V, Achtman, Mark, Sylvain Brisse, Zhou, Zhemin, Harrison, LH, Sangal, V., Nair, Satheesh, Zhemin Zhou, Nair, S., Wain, J., Harrison, Lee H., Uesbeck, A., Bessen, Debra E., Achtman, M., Harrison, L.H., François-Xavier Weill, Vartul Sangal (157216), Mark Achtman, Sylvain Brisse (87594), Dougan, G., Wain, John, Sangal, Vartul, Harbottle, H., Alexandra Uesbeck, Uesbeck Alexandra, Weill, F., Lee H. Harrison (157231), Hale, James L., Lee H Harrison, Heather Harbottle, Hale, James, Dougan Gordon, Krauland, M., Harrison, L., Wain, J, Mark Achtman (126786), James L. Hale (157222), Achtman Mark, Krauland, M.G., Nair Satheesh, François-Xavier Weill (157212), Weill François-Xavier, Harrison, Lee, Mary G Krauland, James L Hale, Dougan, Gordon, Brisse, S, Krauland, Mary, Hale, J., Sangal Vartul, S. Enterica MLST Study Group, Gordon Dougan (30395), Weill, F.X., Uesbeck, A, Satheesh Nair (157213), Krauland, MG, John Wain, Harbottle, H, Harrison Lee H., Krauland Mary G., Dougan, G, Achtman, M, Arias-Pineda, Jesús David, Pitre-Guerrero, Eison Alfredis   +90 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Natural genetic variation impacts expression levels of coding, non‐coding, and antisense transcripts in fission yeast

Molecular Systems Biology, 2014
Our current understanding of how natural genetic variation affects gene expression beyond well‐annotated coding genes is still limited. The use of deep sequencing technologies for the study of expression quantitative trait loci (eQTLs) has the potential ...
Mathieu Clément‐Ziza, Francesc X Marsellach, Sandra Codlin, Manos A Papadakis, Susanne Reinhardt, María Rodríguez‐López, Stuart Martin, Samuel Marguerat, Alexander Schmidt, Eunhye Lee, Christopher T Workman, Jürg Bähler, Andreas Beyer   +12 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Integrated multiple sequence alignment [PDF]

, 2005
Sammeth M. Integrated multiple sequence alignment. Bielefeld (Germany): Bielefeld University; 2005.The thesis presents enhancements for automated and manual multiple sequence alignment: existing alignment algorithms are made more easily accessible and ...
Sammeth, Michael
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Addition of the microchromosome GGA25 to the chicken genome sequence assembly through radiation hybrid and genetic mapping [PDF]

, 2008
BACKGROUND: The publication of the first draft chicken sequence assembly became available in 2004 and was updated in 2006. However, this does not constitute a definitive and complete sequence of the chicken genome, since the microchromosomes are ...
Gourichon, David, Dawson, D.A., Deborah A. Dawson (7630160), Gourichon David, Burke, T., F. Vignoles (7630163), Pitel, F., Burke, Terry, Douaud, Marine,, Dawson Deborah A, Olivier Hanotte (89422), Vignoles, Florence, F., Hanotte, Olivier, M. Douaud (7630142), Gourichon, D., Vignoles, F., Morisson, Mireille, Morrison, M., F. Pitel (7630175), Fillon, Valérie, Vignoles Florence, Fillon, V., D. Gourichon (7630157), Gerus, M., M. Tixier-Boichard (7630169), Dawson, D., Bardes, Suzanne, Vignal Alain, Vignoles, Florence,, Fève Katia, Hanotte, O., Vignoles, Florence, S. Bardes (7630154), Bardes Suzanne, Douaud, M., Gerus Marie, Tixier-Boichard, M., K. Fève (7630145), Terry Burke (80052), Vignal, Alain, Bardes, S., Fève, Katia, Pitel, Frédérique, Dawson, Deborah A., Hanotte, Olivier H., Feve, Katia, K., V. Fillon (7630151), Morisson, M., Douaud, Marine, Morisson Mireille, Tixier-Boichard Michèle, Fillon Valérie, M. Gerus (7630148), Douaud Marine, Tixier-Boichard, Michèle, Douaud, Marine, M., Hanotte Olivier, A. Vignal (7630172), M. Morisson (7630166), Dawson, Deborah A, Pitel Frédérique, Gerus, Marie, Feve, Katia,, Vignal, A., Burke Terry, Fève, K.   +65 more
core   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source