Results 181 to 190 of about 5,758,485 (356)

The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species [PDF]

open access: gold, 2016
Alexie Papanicolaou   +63 more
openalex   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Guide for phenotype-specific profiling of DNA G-quadruplex-regulated genes

open access: yesSTAR Protocols
Summary: DNA G-quadruplex (G4) is a non-canonical four-stranded secondary structure that has been shown to play a role in epigenetic modulation of gene expression.
Zhuoyang Zhao   +3 more
doaj  

Implications of the use of experimental activities in biology education in public schools

open access: yesInvestigações em Ensino de Ciências, 2016
This study aimed to verify the influence of a didactic sequence with experimental activities on student motivation in relation to the subject matter Biology and check the possibility of applying such a result having as input the cultural-historical ...
Vânia Cardoso da Silva Morais   +1 more
doaj  

Erratum to “Using HIV-1 sequence variability to explore virus biology”

open access: bronze, 2001
Kathryn M McGrath   +4 more
openalex   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Sequência didática baseada na pedagogia histórico-crítica para abordar o Papilomavírus Humano (HPV) no ensino médio

open access: yesRevista de Estudos e Pesquisas sobre Ensino Tecnológico, 2017
The present work proposes a didactic sequence to discuss the vaccine importance and the condoms use as human papillomavirus prevention. This experiment was carried out in a public school in Manaus, during biology classes at two classes in the 3rd year of
Elisângela Cavalcante de Oliveira   +2 more
doaj  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

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