Results 271 to 280 of about 1,274,222 (313)

Predictive modeling of gene expression and localization of DNA binding site using deep convolutional neural networks. [PDF]

PLoS Comput Biol
Karshenas A, Röschinger T, Garcia HG.
europepmc   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Cell type annotation for scATAC-seq via DNA large language model and graph domain adaptation. [PDF]

PLoS Comput Biol
Liu Y, Guan S, Yan H, Shen LC, Qiang JP, Wei G.   +5 more
europepmc   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

An entropy-based framework for genomic variability analysis: A South American case study of human papillomavirus. [PDF]

PLoS One
López Leal A, Valdés-Muñoz E, Faundez-Acuña JY, Rojas-Pérez V, D Afonseca V, Silva-Aravena F.   +5 more
europepmc   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Advances and opportunities for computational interrogation of plant proteins. [PDF]

Plant J
Bohling SM, Musharoff S, Gunn LH.
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Computational models for the classification of antibody specificity using heavy chain features. [PDF]

PLoS One
Lin J, Chen J, Wan L, He W, Zhu Y, Qiao M, Meng F, Lin D, Che Y, Cao Z.   +9 more
europepmc   +1 more source

CodonMoE: DNA language models for codon-dependent mRNA prediction. [PDF]

Bioinformatics
Du S, Liang L, Li J, Kingsford C.
europepmc   +1 more source