Results 251 to 260 of about 1,274,222 (313)

MsgaBpred: A B-cell epitope predictor integrating AlphaFold3-predicted structures with multi-scale GCNs and pre-trained language model ESM-C. [PDF]

PLoS Comput Biol
Wang S, Geng A, Luo Z, Li Y, Xu J, Meng Y, Wei L, Zou Q, Zhang Z, Wang T, Cui F.   +10 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

The regulation of Xrp1 expression by uORFs and main ORF sequences and its function in Drosophila disease models. [PDF]

PLoS Genet
Katow H, Nguyen T, Park SH, Ryoo HD.
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Corrigendum: Sequence Analysis of Two B1 Mycobacteriophages, ElvisPhasley and Mesmerelda. [PDF]

MicroPubl Biol
europepmc   +1 more source

Sequencing complete plasmids on Oxford Nanopore Technologies sequencers using R2C2 and Chopper. [PDF]

PLoS One
Schimke KD, Vollmers C.
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Genome Sequence and Host Range Investigation of Cluster CV Phage Spink. [PDF]

MicroPubl Biol
Smith E, Cordero-Morales AE, Padilla-Crespo E, Tan EH, Reyna N, Plymale R.   +5 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Longitudinal lineage tracing reveals early clonal attrition during Drosophila midgut aging. [PDF]

PLoS Biol
Gong H, Liu K, Deng S, Wang J, He X, Liu L.   +5 more
europepmc   +1 more source