Results 81 to 90 of about 8,102,704 (303)
Massive Sequence Comparisons as a Help in Annotating Genomic Sequences [PDF]
Genome Research, 2001 An all-by-all comparison of all the publicly available protein sequences from plants has been performed, followed by a clusterization process. Within each of the 1064 resulting clusters—containing sequences that are orthologous as well as paralogous—the sequences have been submitted to a pyramidal classification and their domains delineated by an ...
Louis, Alexandra +3 more
openaire +3 more sources
, 2022 Comparison of the enhancer II region amino acid sequence with the reference sequence (Normal) showing amino acid substitutions and deletions.
Muhammad Nasir Khabir (11902205) +11 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An iterative method for faster sum-of-pairs multiple sequence alignment [PDF]
, 2000 Reinert K, Stoye J, Will T. An iterative method for faster sum-of-pairs multiple sequence alignment. Bioinformatics.
Stoye, Jens ; https://orcid.org/ +2 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Sequence comparison on the connection machine
Concurrency: Practice and Experience, 1991 AbstractWe give two parallel algorithms for sequence comparison on the Connection Machine 2 (CM‐2). The specific comparison measure we compute is theedit distance: given a finite alphabet ∑ and two input sequencesXϵ ∑+andYϵ ∑+the edit distanced(X,Y)is the minimum cost of transformingXintoYvia a series of weighted insertions, deletions and substitutions
Atallah, Mikhail J., McFaddin, Scott
openaire +3 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Comparison study on k-word statistical measures for protein: From sequence to 'sequence space'
BMC Bioinformatics, 2008 Background Many proposed statistical measures can efficiently compare protein sequence to further infer protein structure, function and evolutionary information. They share the same idea of using k-word frequencies of protein sequences.
Wang Tianming, Dai Qi
doaj +1 more source
A comprehensive comparison of comparative RNA structure prediction approaches [PDF]
, 2004 Gardner PP, Giegerich R. A comprehensive comparison of comparative RNA structure prediction approaches. BMC Bioinformatics. 2004;5(1): 140.Background: An increasing number of researchers have released novel RNA structure analysis and prediction ...
Giegerich, R. +7 more
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source