Results 31 to 40 of about 104,871 (266)

Genome-wide association study of rubella virus vaccine strain BRD-Ⅱ

Shanghai yufang yixue
ObjectiveTo perform a genome-wide association study of rubella virus vaccine strain BRD-Ⅱ, so as to fully grasp the sequence characteristics of this genome.MethodsSecond-generation sequencing method was used to conduct the whole-genome sequencing on the ...
XU Yingmei, ZHU Yongqiang, ZHOU Xin, LIU Zhaoyang, MA Leijun, CHEN Zhewen, ZHAO Yueye, ZHU Tiaoxia   +7 more
doaj   +1 more source

In silico PCR analysis: a comprehensive bioinformatics tool for enhancing nucleic acid amplification assays

Frontiers in Bioinformatics
Nucleic acid amplification assays represent a pivotal category of methodologies for targeted sequence detection within contemporary biological research, boasting diverse utility in diagnostics, identification, and DNA sequencing.
Ruslan Kalendar, Ruslan Kalendar, Alexandr Shevtsov, Zhenis Otarbay, Aisulu Ismailova   +4 more
doaj   +1 more source

Deoxyhypusine hydroxylase from Plasmodium vivax, the neglected human malaria parasite: molecular cloning, expression and specific inhibition by the 5-LOX inhibitor zileuton. [PDF]

PLoS ONE, 2013
Primaquine, an 8-aminoquinoline, is the only drug which cures the dormant hypnozoites of persistent liver stages from P. vivax. Increasing resistance needs the discovery of alternative pathways as drug targets to develop novel drug entities ...
Veronika Anyigoh Atemnkeng, Mario Pink, Simone Schmitz-Spanke, Xian-Jun Wu, Liang-Liang Dong, Kai-Hong Zhao, Caroline May, Stefan Laufer, Barbara Langer, Annette Kaiser   +9 more
doaj   +1 more source

Testing robustness of relative complexity measure method constructing robust phylogenetic trees for Galanthus L. Using the relative complexity measure [PDF]

, 2013
Background: Most phylogeny analysis methods based on molecular sequences use multiple alignment where the quality of the alignment, which is dependent on the alignment parameters, determines the accuracy of the resulting trees.
Sırrı Yüzbaşıoğlu, Taşçı Nivart, O Uğur Sezerman, Bakis, Yasin, Yuzbasioglu, Sirri, Neş’e Bilgin, Sezerman O Uğur, Cem Meydan, Yasin Bakış, Bakış Yasin, Sezerman, Uğur, Taşçı, Nivart, Bilgin, Nes'e, Bilgin, Neşe, Yüzbaşıoğlu, Sırrı, Meydan Cem, Bakış, Yasin, Otu Hasan H, Sezerman, O. Ugur, Meydan, Cem, Yüzbaşıoğlu Sırrı, Otu, Hasan H., Hasan H Otu, Nivart Taşçı, Tasci, Nivart, Bilgin Neş’e   +25 more
core   +1 more source

Nucleic Acid Probes in Microbiology

, 2013
Single-stranded nucleic acid molecules can interact under certain conditions with other nucleic acids in the regions of base complementarily to form double-stranded hybrid molecules. From measurement of kinetics of the hybridisation and the extent of
Venkateswaran, K.S., Venkateswaran, Neeraja   +1 more
core   +1 more source

Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis. [PDF]

, 2010
TGR5, the G protein-coupled bile acid receptor 1 (GPBAR1), has been linked to inflammatory pathways as well as bile homeostasis, and could therefore be involved in primary sclerosing cholangitis (PSC) a chronic inflammatory bile duct disease. We aimed to
Bergquist Annika, Melum, E., Andreas Teufel, Franke Andre, Ellinghaus Eva, Michael P. Manns, Benedicte A Lie, Stokkers, Pieter C. F., Stokkers, P.C.F., Weismueller, Tobias, Manns, M., Beuers Ulrich, Mathew, C., Keitel, V., Schramm Christoph, Bergquist, A., Weersma, R., Vatn, M., Christian Rust, Vatn, Morten H, Christoph Schramm, Hov, Johannes R, Stiehl Adolf, Ponsioen, C., Teufel, A., Rust Christian, Ponsioen, Cyriel Y, Henckaerts, L., Schrumpf, E., Erik Schrumpf, Balschun, T., Haeussinger, Dieter, Lie, B., Franke, Andre, Pieter C F Stokkers, Espen Melum, Annika Bergquist, Mathew, Christopher G, Melum, Espen, Spomer Lina, Boberg, K., Häussinger, D., Jon K. Laerdahl, null null, Daniel Gotthardt, Onnie Clive M., Franke, A., Beuers, U., Eva Ellinghaus, Wijmenga, Cisca, IBSEN Study Group, Laerdahl, J.K., Vatn, Morten H., Cisca Wijmenga, Gotthardt Daniel, Weersma, Rinse K., Hov Johannes R., Stokkers Pieter C. F., Beuers, Ulrich, Keitel Verena, Boberg Kirsten M., ElSharawy, Abdou, Mathew, Christopher G.; id_orcid, Vatn Morten H., Johannes R. Hov, Lie, Benedicte A., Häussinger, Dieter, Hov, J.R., Runz Heiko, Schrumpf Erik, Onnie, C.M., Liesbet Henckaerts, Vermeire, S., Weismüller, T., Teufel Andreas, Bergquist, Annika, Dieter Häussinger, Mathew Christopher G., Karlsen, T.H., Karlsen Tom H., Lie, B.A., Morten H Vatn, Keitel, Verena, Spomer, Lina, Onnie, C., Mathew, Christopher G., Stokkers, Pieter C F, Morten H. Vatn, Manns, Michael P, Weersma, R.K., ElSharawy Abdou, Jon K Laerdahl, Vermeire, Severine, Schreiber Stefan, Christopher G Mathew, Melum Espen, Tobias Weismüller, Henckaerts Liesbet, Onnie, Clive M., Tom H Karlsen, Ponsioen, C.Y., Ellinghaus, Eva, Manke Thomas, Onnie, Clive M, Runz, H., Schreiber, Stefan, Cyriel Y Ponsioen, Kirsten M. Boberg, Laerdahl, Jon K, Stokkers, P., Wijmenga, C., Wijmenga Cisca, Schreiber, S., Lina Spomer, Abdou ElSharawy, Lie, Benedicte A, Weersma, Rinse K, Stiehl, A., Stefan Schreiber, Severine Vermeire, Kirsten M Boberg, Adolf Stiehl, Weersma, Rinse K.; id_orcid, Schrumpf, Erik, Boberg, K.M., Stiehl, Adolf, Heiko Runz, Weismüller Tobias, Schramm, C., Sterneck, Martina, Gotthardt, D., Rinse K. Weersma, Ellinghaus, E., Boberg, Kirsten M., Verena Keitel, Spomer, L., Wijmenga, Cisca; id_orcid, Manke, Thomas, Elsharawy, A., Cyriel Y. Ponsioen, Schramm, Christoph, Vermeire Severine, Tobias Balschun, Karlsen, Tom H, Laerdahl, Jon K., Rust, C., Karlsen, T., Runz, Heiko, Manns Michael P., Laerdahl, J., Clive M Onnie, Teufel, Andreas, Martina Sterneck, Lie Benedicte A., Sterneck Martina, Häussinger Dieter, Christopher G. Mathew, Laerdahl Jon K., Weersma Rinse K., Mathew, C.G., Weismüller, Tobias, Henckaerts, Liesbet, Ponsioen, Cyriel Y., Boberg, Kirsten M, Benedicte A. Lie, Andre Franke, Sterneck, M., Ulrich Beuers, Thomas Manke, Vatn, M.H., Johannes R Hov, Ponsioen Cyriel Y., Manke, T., Karlsen, Tom H., Rinse K Weersma, Balschun Tobias, Pieter C. F. Stokkers, Balschun, Tobias, Hov, Johannes R., Hov, J., Tom H. Karlsen, Manns, Michael P., Manns, M.P., Michael P Manns, Gotthardt, Daniel, Rust, Christian, Clive M. Onnie   +186 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The Historical Evolution and Significance of Multiple Sequence Alignment in Molecular Structure and Function Prediction

Biomolecules
Multiple sequence alignment (MSA) has evolved into a fundamental tool in the biological sciences, playing a pivotal role in predicting molecular structures and functions.
Chenyue Zhang, Qinxin Wang, Yiyang Li, Anqi Teng, Gang Hu, Qiqige Wuyun, Wei Zheng   +6 more
doaj   +1 more source

Multi-host model-based identification of Armillifer agkistrodontis (Pentastomida), a new zoonotic parasite from China. [PDF]

PLoS Neglected Tropical Diseases, 2010
BACKGROUND: Pentastomiasis is a rare parasitic infection of humans. Pentastomids are dioecious obligate parasites requiring multiple hosts to complete their lifecycle. Despite their worm-like appearance, they are commonly placed into a separate sub-class
Shao-Hong Chen, Qin Liu, Yong-Nian Zhang, Jia-Xu Chen, Hao Li, Ying Chen, Peter Steinmann, Xiao-Nong Zhou   +7 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source