Results 41 to 50 of about 104,871 (266)

Seroepidemiological investigation of Getah virus in the China-Myanmar border area from 2022-2023

Frontiers in Microbiology, 2023
Getah Virus (GETV) is an RNA virus that is transmitted by mosquitoes and can cause disease or death in a variety of vertebrates. Its prevalence is increasingly severe in Asia. This study conducted a GETV epidemiological investigation on 1,300 bovine sera
Hao Liu, Jin Hu, Li-Xia Li, Zi-Shuo Lu, Xiu-Tao Sun, Hui-Jun Lu, Ning-Yi Jin, Lei Zhang, Li-Na Zhang   +8 more
doaj   +1 more source

Exploring Protein Sequence Space Using Computationally Directed Recombination [PDF]

, 2006
Evolution has provided us with many protein sequences. However, these sequences represent a very small fraction of the possible sequences. In the laboratory, scientists have explored areas of sequence space not represented by natural proteins both to ...
Meyer, Michelle Margaret
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Reassortment and genomic analysis of a G9P[8]-E2 rotavirus isolated in China

Virology Journal, 2023
Objective To isolate a prevalent G9P[8] group A rotavirus (RVA) (N4006) in China and investigate its genomic and evolutionary characteristics, with the goal of facilitating the development of a new rotavirus vaccine.
Rui Peng, Dandi Li, Jindong Wang, Guangping Xiong, Mengxuan Wang, Dan Liu, Yuhang Wei, Lili Pang, Xiaoman Sun, Huiying Li, Xiangyu Kong, Saleha Shahar, Zhaojun Duan   +12 more
doaj   +1 more source

CandidaDB : a genome database for Candida albicans pathogenomics [PDF]

, 2005
Open Access via PMC540078Non peer ...
Frangeul, L, Jones, L, Martin, N, Castillo, L., Gaillardin, C., Fradin, C, Gaillardin, Claude, Brown, A J P, Tekaia, F., Albrecht, A, Sentandreu, R., Ernst, J.F., Lopez, M.-C., Lopez, M.C., Kunze, D., Bader, O., Castillo, L, Dominguez, A, Goyard, S., Rodriguez-Arnaveilhe, S., Frangeul, L., Lopez, M C, Klis, F., Mavor, A, Onesime, D, Fradin, C., Brown, A.J.P., Onésime, D., Goyard, S, Valentin, E, d'Enfert, C., Onesime, Djamila,, Ernst, J F, Hube, B., Onesime, Djamila, de Groot, P, Martin, N., Gaillardin, C, Krishnamurthy, S, Klis, F M, Sentandreu, R, Valentin, E., Dominguez, A., Moszer, I., D'Enfert, Christophe, Rodriguez-Arnaveilhe, S, de Groot, P., Krishnamurthy, S., Albrecht, Antje, Garcia-Sanchez, S., Hube, B, Brown, J.P., d'Enfert, C, Moszer, I, Perez Martin, J., Garcia-Sanchez, S, Klis, F.M., Kunze, D, Mavor, A., Tekaia, F, Martin, J P, Jones, L., D'Enfert, Christpohe, Bader, O, Albrecht, A., de Garcia-Sanchez, S., Dominguez, Angel, Krishnamurty, S.   +67 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A special satellite-like RNA of a novel hypovirus from Pestalotiopsis fici broadens the definition of fungal satellite.

PLoS Pathogens, 2023
Satellites associated with plant or animal viruses have been largely detected and characterized, while those from mycoviruses together with their roles remain far less determined.
Zhenhao Han, Jiwen Liu, Linghong Kong, Yunqiang He, Hongqu Wu, Wenxing Xu   +5 more
doaj   +1 more source

Primary structure of potato Kunitz-type serine proteinase inhibitor [PDF]

, 2000
The serine proteinase inhibitor (PSPI-51) isolated from potato tubers (Solanum tuberosum L,) comprises two protein species with pi 5.2 and 6.3, denoted as PSPI-21-5.2 and PSPI-21-6.3, respectively.
Mentele, Reinhard, Valueva, Tatyana A., Revina, Tatyana A., Mosolov, Vladimir V.   +3 more
core   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source