Results 111 to 120 of about 660,133 (262)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Sampling of structure and sequence space of small protein folds. [PDF]

Nat Commun, 2022
Linsky TW, Noble K, Tobin AR, Crow R, Carter L, Urbauer JL, Baker D, Strauch EM.   +7 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

An objective criterion to evaluate sequence-similarity networks helps in dividing the protein family sequence space. [PDF]

PLoS Comput Biol, 2023
Hornung BVH, Terrapon N.
europepmc   +1 more source

Matrix Transformations of Some Generalized Sequence spaces into semiperiodic Sequence Space

Communications, Faculty Of Science, University of Ankara Series A1Mathematics and Statistics, 1961
Necessary and sufficient conditions have been established on an infinite matris A = (ap]^) to transform the generalized segnence spaces 1 (p), Cp(p) and 1„ (p) into, q, the spa,ce of semipe­ riodic seguences. The special case when pjj = 1 /t gives Cp(p) and Ijo (p) es T and ,T* the spaces introdueed by V. Ganapathy lyer [2].
openaire   +3 more sources

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Unifying the known and unknown microbial coding sequence space. [PDF]

Elife, 2022
Vanni C, Schechter MS, Acinas SG, Barberán A, Buttigieg PL, Casamayor EO, Delmont TO, Duarte CM, Eren AM, Finn RD, Kottmann R, Mitchell A, Sánchez P, Siren K, Steinegger M, Gloeckner FO, Fernàndez-Guerra A.   +16 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

On learning functions over biological sequence space: relating Gaussian process priors, regularization, and gauge fixing. [PDF]

J Math Biol
Petti S, Martí-Gómez C, Kinney JB, Zhou J, McCandlish DM.   +4 more
europepmc   +2 more sources

Fine Sampling of Sequence Space for Membrane Protein Structural Biology. [PDF]

J Mol Biol, 2021
Loukeris M, Sanghai ZA, Vendome J, Hendrickson WA, Kloss B, Mancia F.   +5 more
europepmc   +1 more source