Results 51 to 60 of about 7,026,554 (307)

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Ewing Sarcoma in Infants and Children Under 2 Years of Age: A French Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ewing sarcoma, the second most common primary bone cancer in children, requires intensive treatment that may lead to significant long‐term sequelae, particularly in infants. We retrospectively analyzed data from 1621 French patients treated between 1988 and 2015 within the EW88/93/97 or EE99 trials, focusing on 17 infants diagnosed before 24 ...
Elodie Verdier, Nathalie Cozic, Marie‐Dominique Tabone, Gaelle Pierron, Perrine Marec‐Berard, Sarah Winter, Gabriel Revon‐Rivière, Cyril Lervat, Dominique Plantaz, Marie‐Pierre Castex, Gregory Guimard, Estelle Thebaud, Stephanie Proust, Laure Saumet, Natacha Entz‐Werle, Sophie Taque, Cécile Vérité, Marta Jimenez, Nathalie Gaspar   +18 more
wiley   +1 more source

Characteristics of Streptococcus pneumoniae carriage in the pediatric population

Журнал микробиологии, эпидемиологии и иммунобиологии
Objective: to investigate the regional peculiarities of Streptococcus pneumoniae carriage in the pediatric population and characterize the dominant serotypes of the pathogen. Materials and methods.
Guzel S. Isaeva, Albina Z. Zaripova, Lira T. Bayazitova, Ralina M. Khusainova, Tatiana A. Chazova, Olga F. Tyupkina, Ekaterina V. Nikitina, Irina A. Tsvetkova   +7 more
doaj   +1 more source

Molecular Characterization of German Acinetobacter baumannii Isolates and Multilocus Sequence Typing (MLST) Analysis Based on WGS Reveals Novel STs

Pathogens, 2021
Acinetobacter baumannii (A. baumannii) is a major cause of severe nosocomial infections worldwide. The emergence of infections associated with A. baumannii poses a significant health risk in Germany. A.
Gamal Wareth, Jörg Linde, Philipp Hammer, Wolf D. Splettstoesser, Mathias W. Pletz, Heinrich Neubauer, Lisa D. Sprague   +6 more
doaj   +1 more source

A Situational Assessment of the Diagnostic Landscape and Organizational Readiness to Implement Next‐Generation Sequencing at Two Childhood Cancer Treatment Centers in Ghana

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Next‐generation sequencing (NGS) has emerged as a promising approach to improve diagnostic accuracy, but its feasibility in low‐ and middle‐income countries remains unknown. This study characterized the diagnostic landscape and assessed organizational readiness for NGS implementation at two childhood cancer treatment centers in Accra ...
Melissa Carvalho, Emmanuella Amoako, Nihad Salifu, Lily Gloria Tagoe, Yaw Bediako, Michelle Hermiston, Catherine Segbefia   +6 more
wiley   +1 more source

Deciphering vancomycin resistance in Enterococcus faecium: gene distribution, sequence typing, and global phylogenetic analysis

Frontiers in Microbiology
ObjectiveThis study analyzes the global prevalence and distribution of vancomycin resistance genes (van) in Enterococcus faecium and examines the genetic relationship and epidemiological characteristics of strains carrying these genes.MethodA total of 3 ...
Ruyu Yan, Jun Ji, Han Shen, Xiaoli Cao, Xiaoli Cao   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

High-risk clonal groups of avian pathogenic Escherichia coli (APEC) demonstrate heterogeneous phenotypic characteristics in vitro and in vivo

Virulence
Avian Pathogenic Escherichia coli (APEC), a major bacterial pathogen of poultry, comprises a diverse range of high-risk clonal groups. However how these lineages interact with avian host cells remains poorly characterized. This study examined the ability
James R. G. Adams, Huijun Long, Charlotte A. Birdsall, Kamran Qureshi, Emma King, Sara Perez, Keith Warner, Shahriar Behboudi, Roberto M. La Ragione, Jai W. Mehat   +9 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

High clonal diversity, resistome, and virulome of Escherichia coli causing sepsis in Ethiopian tertiary hospitals: a multicenter genomic study

Frontiers in Microbiology
BackgroundWHO-priority multidrug-resistant (MDR) Escherichia coli poses major global health challenges, especially in low- and middle-income countries.MethodsFrom October 2019 to September 2020, a multicenter study was conducted at Tikur Anbessa ...
Melese Hailu Legese, Melese Hailu Legese, Melese Hailu Legese, Melese Hailu Legese, Daniel Asrat, Dejenie Shiferaw Teklu, Badrul Hasan, Adane Mihret, Adane Mihret, Abraham Aseffa, Göte Swedberg   +10 more
doaj   +1 more source