Results 221 to 230 of about 6,337,317 (349)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Another host, another mystery: Infection of polychaete Pista palmata (Annelida: Terebellidae) with a new blood fluke (Digenea: Aporocotylidae) in the coastal Northwest Atlantic Ocean. [PDF]

Parasite
Chowansky AN, Hill-Spanik KM, Kyle DE, de Buron I.   +3 more
europepmc   +1 more source

Distribution of repetitive DNA sequences in eubacteria and application to fingerprinting of bacterial genomes.

Nucleic Acids Research, 1991
J. Versalovic, T. Koeuth, J. Lupski
semanticscholar   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Unveiling the terra cognita of sequence spaces using Cartesian projection of asymmetric distances. [PDF]

NAR Genom Bioinform
Ramette A.
europepmc   +1 more source

Evolutionary relationship of DNA sequences in finite populations.

Genetics, 1983
F. Tajima
semanticscholar   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

A next-generation sequencing approach for high-resolution S-locus genotyping in apricot. [PDF]

Sci Rep
Lora J, Torres A, Hormaza JI, Rodrigo J, Hedhly A.   +4 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Confocal laser microendoscopy characterization of vascular features in facial basal cell carcinoma: a comparative analysis of tumor and adjacent healthy tissue. [PDF]

Lasers Med Sci
Müller-Diesing F, Sievert M, Aubreville M, Hackenberg S, Panuganti B, Klein M, Porsche N, Scherzad A, Stöth M, Winnand P, Wirth M, Goncalves M.   +11 more
europepmc   +1 more source