Results 71 to 80 of about 3,116,462 (307)
Large scale hierarchical clustering of protein sequences [PDF]
, 2005 Krause A, Stoye J, Vingron M. Large scale hierarchical clustering of protein sequences. BMC Bioinformatics. 2005;6(1): 15.Background: Searching a biological sequence database with a query sequence looking for homologues has become a routine operation in ...
Stoye Jens +11 more
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Assessing Incrementality in Sequence-to-Sequence Models [PDF]
Proceedings of the 4th Workshop on Representation Learning for NLP (RepL4NLP-2019), 2019 Since their inception, encoder-decoder models have successfully been applied to a wide array of problems in computational linguistics. The most recent successes are predominantly due to the use of different variations of attention mechanisms, but their cognitive plausibility is questionable.
Ulmer, D., Hupkes, D., Bruni, E.
openaire +5 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Modeling Confidence in Sequence-to-Sequence Models [PDF]
Proceedings of the 12th International Conference on Natural Language Generation, 2019 Recently, significant improvements have been achieved in various natural language processing tasks using neural sequence-to-sequence models. While aiming for the best generation quality is important, ultimately it is also necessary to develop models that can assess the quality of their output.
Niehues, J., Pham, N.-Q.
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Finding Repeated Flexible Relational Words in Sequences [PDF]
Journal of Systemics, Cybernetics and Informatics, 2004 Finding regularities in sequences is an important problem in various areas. Regularities are often words (in a strict or somewhat flexible meaning) "repeated" in the sequence, i.e. satisfying some constraints about their occurrence. In this paper we deal
Nahla EL ZANT EL KADHI, Henry SOLDANO
doaj
Sigma function solution of the initial value problem for Somos 5 sequences [PDF]
, 2007 The Somos 5 sequences are a family of sequences defined by a fifth order bilinear recurrence relation with constant coefficients. For particular choices of coefficients and initial data, integer sequences arise.
Hone, Andrew N.W.
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