Results 41 to 50 of about 16,735 (263)

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo   +5 more
wiley   +1 more source

Multi-objective optimization in plastic injection molding with injection and packing time

open access: yesNihon Kikai Gakkai ronbunshu, 2015
Plastic injection molding (PIM) is one of the most important manufacturing processes for producing plastic products. The process parameters in the PIM, such as mold temperature, melt temperature, and injection pressure affect the product quality and the ...
Shinji NATSUME, Satoshi KITAYAMA
doaj   +1 more source

Determination of back-pressure profile and slide motion of servo press in cold forging using sequential approximate optimization

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2020
Forging is one of the important manufacturing technologies to produce various mechanical components with high productivity. Recently, servo press that can control the back-pressure and the slide motion during the forging has attracted attention for high ...
Satoshi KITAYAMA   +3 more
doaj   +1 more source

Sequential approximate optimality conditions for multi objective fractional programming problems via sequential approximate subdifferential calculus

open access: yesLe Matematiche, 2021
The author provides a sequential subdifferential calculus rule for the sums of $p\) (\(p\geq 2$) scalar functions and the composition of a scalar and vector mapping under convexity and lower semicontinuity hypotheses without assuming qualification conditions. By applying this result, the author presents, without any constraint qualification, sequential
M. B. Moustaid   +3 more
openaire   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reentry Vehicle Intelligent Trajectory Convex Optimization Method Based on Terminal Time Prediction

open access: yesAerospace
To address the efficiency problem of traditional sequential convex optimization (SCO) methods with uncertain terminal time for long-range hypersonic vehicle reentry, this paper proposes an improved method with neural network-based terminal time ...
Feng Yang   +3 more
doaj   +1 more source

Multi-objective optimization of process parameters in plastic injection molding using variable pressure profile

open access: yesNihon Kikai Gakkai ronbunshu, 2017
Process parameters in plastic injection molding (PIM) such as packing pressure, melt temperature and cooling time have a direct influence on the product quality and it is important to determine the optimal process parameters for the high product quality ...
Masaki YOKOYAMA   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

A Data-Driven Sequential Adaptive Optimization Method for Lightweight Design of Complex Vehicle Structures

open access: yesApplied Mechanics
To address high-dimensional coupling and extrapolation errors in vehicle lightweighting, this paper proposes a “Macroscopic Topology—Microscopic Data-Driven Size Synergy” methodology.
Yuxuan Wang   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

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