Results 41 to 50 of about 18,713 (263)

Multi-objective optimization in plastic injection molding with injection and packing time

Nihon Kikai Gakkai ronbunshu, 2015
Plastic injection molding (PIM) is one of the most important manufacturing processes for producing plastic products. The process parameters in the PIM, such as mold temperature, melt temperature, and injection pressure affect the product quality and the ...
Shinji NATSUME, Satoshi KITAYAMA
doaj   +1 more source

Sequential approximate optimality conditions for multi objective fractional programming problems via sequential approximate subdifferential calculus

Le Matematiche, 2021
The author provides a sequential subdifferential calculus rule for the sums of $p\) (\(p\geq 2$) scalar functions and the composition of a scalar and vector mapping under convexity and lower semicontinuity hypotheses without assuming qualification conditions. By applying this result, the author presents, without any constraint qualification, sequential
M. B. Moustaid, M. Laghdir, I. Dali, A. Rikouane   +3 more
openaire   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A Data-Driven Sequential Adaptive Optimization Method for Lightweight Design of Complex Vehicle Structures

Applied Mechanics
To address high-dimensional coupling and extrapolation errors in vehicle lightweighting, this paper proposes a “Macroscopic Topology—Microscopic Data-Driven Size Synergy” methodology.
Yuxuan Wang, Chenlin Zhang, Hao Liu, Zhaohui Hu   +3 more
doaj   +1 more source

Multi-objective optimization of process parameters in plastic injection molding using variable pressure profile

Nihon Kikai Gakkai ronbunshu, 2017
Process parameters in plastic injection molding (PIM) such as packing pressure, melt temperature and cooling time have a direct influence on the product quality and it is important to determine the optimal process parameters for the high product quality ...
Masaki YOKOYAMA, Satoshi KITAYAMA, Masahiro TAKANO, Shuji AIBA   +3 more
doaj   +1 more source

Determination of back-pressure profile and slide motion of servo press in cold forging using sequential approximate optimization

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2020
Forging is one of the important manufacturing technologies to produce various mechanical components with high productivity. Recently, servo press that can control the back-pressure and the slide motion during the forging has attracted attention for high ...
Satoshi KITAYAMA, Tsubasa HIGUCHI, Masahiro TAKANO, Akio KOBAYASHI   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Reentry Vehicle Intelligent Trajectory Convex Optimization Method Based on Terminal Time Prediction

Aerospace
To address the efficiency problem of traditional sequential convex optimization (SCO) methods with uncertain terminal time for long-range hypersonic vehicle reentry, this paper proposes an improved method with neural network-based terminal time ...
Feng Yang, Geng Tian, Ziheng Cheng, Kai Liu   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source