Results 81 to 90 of about 8,156 (254)

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

MRI after Sequential Use of Gadolinium Chelate and Mangafodipir Trisodium for the Evaluation of Focal Liver Lesions: Study of Image Findings and Safety

Journal of the Korean Radiological Society, 2002
Purpose: To assess the feasibility of sequentially administering Gd-DTPA and Mn-DPDP for the MR imaging of focal hepatic lesions, and to investigate whether the procedures involved led to any adverse effects. Materials and Methods: Forty-two patients (M:F=25:17) with suspected hepatic lesions underwent T1-weighted MR imaging procedures before and after
Jae Joon Chung, Myeong Jin Kim, Joo Hee Kim, Jong Tae Lee, Hyung Sik Yoo   +4 more
openaire   +1 more source

Nanoporous Silver with Controllable Optical Properties Formed by Chemical Dealloying in Supercritical CO₂

, 2016
Nanoporous Ag was formed by selectively etching Cu from multiphase AgCu alloys using the oxidant hydrogen peroxide and the metal chelator hexafluoroacetylacetone (hfacH, 14 mM) dissolved in supercritical CO2 (60 °C and 16 MPa).
Anthony J. Muscat (1556878), Rachel Morrish (1782016)   +1 more
core   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Highly Regioselective, Sequential, and Multiple Palladium-Catalyzed Arylations of Vinyl Ethers Carrying a Coordinating Auxiliary:  An Example of a Heck Triarylation Process

, 2016
This article describes the development of new auxiliary-accelerated Heck multiarylations by intramolecular presentation of the oxidative addition complex.
Mats Larhed (492164), Peter Nilsson (3305), Anders Hallberg (585061)   +2 more
core   +2 more sources

Significant Suppression of the Colony Forming Capacity of Erythroid Progenitors by Iron Overload in Patients with MDS and Sequential Anlyses of BFU-E Under Chelation Therapy.

Blood, 2009
Abstract Abstract 3826 Poster Board III-762 Introduction The majority of patients with MDS depend on regular blood cell (RBC) transfusions during the course of their disease. Patients with lower-risk MDS are at particularly high risk of developing iron overload because of
Hartmann, Julia, Sinzig, Ursula, Wulf, Gerald, Truemper, Lorenz H., Konietschke, Frank, Fischer, Stephanie, Haase, Detlef   +6 more
openaire   +2 more sources

A chemical mechanism for tissue staining by osmium tetroxide-ferrocyanide mixtures.

, 1979
The presence of Fe(CN)6(-4) provides sequential, one-electron reduction pathways for OSO4. An equilibrium is established containing OSO4, Fe(CN)6(-4), Fe(CN)6(-3), OSO2(OH)4(-4), and labile cyano-bridged OS-Fe species containing Os in nominal oxidation ...
R J Barrnett, D L White, J E Mazurkiewicz   +2 more
core   +1 more source

Quantitative Mass Spectrometry‐Based Biodistribution of Monoclonal Antibodies: An Alternative to Radio‐Biodistribution

Advanced Science, EarlyView.
Monoclonal antibodies are powerful anticancer therapeutics targeting tumor‐associated antigens. Mass spectrometry enables precise and accurate quantification of mAbs in tumor plasma and healthy organs. Unlike ligand binding assay and radioactivity, mass spectrometry does not suffer from matrix effects and labelling artefacts while facilitating method ...
Domenico Ravazza, Sheila Dakhel Plaza, Samuele Cazzamalli, Andrea Ciamarone, Andrea Galbiati, Riccardo Stucchi, Frederik Peissert, Emanuele Puca, Dario Neri, Ettore Gilardoni   +9 more
wiley   +1 more source

Improving survival with deferiprone treatment in patients with thalassemia major: A prospective multicenter randomised clinical trial under the auspices of the Italian Society for Thalassemia and Hemoglobinopathies

, 2009
The prognosis for thalassemia major has dramatically improved in the last two decades. However, many transfusion-dependent patients continue to develop progressive accumulation of iron.
Filosa, A, VITRANO, Angela, Rizzo, M, Giuffrida, G, Giugno, G, Gagliardotto, F, Meo, A, Campisi, S, Maggio, A, Caruso, V, Rigano, P., Cianciulli, P, Magnano, C, Violi, P, D’Ascola, DG, Lombardo, T, Ciancio, A, Capra, M, Roccamo, G, Malizia, R, Commendadore, F, Cantella, F, Argento, C, Fidone, C, Cingari, R, Cuccia, L, Prossomariti, L, Galati, MC, Romeo, MA, Gerardi, C   +29 more
core   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source