Results 91 to 100 of about 214,226 (302)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Arts In Focus [PDF]

open access: yes, 2001
Arts in Focus: Los Angeles Countywide Arts Education Survey is the largest, most detailed survey on arts education in Los Angeles County, the most populous county in the United States.

core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Categorizing learners’ needs in English for occupational purposes (EOP): a proposed taxonomy

open access: yesInsights into Language, Culture and Communication
Teaching English for Specific purposes (ESP) necessitates exerting tremendous efforts and carrying out tasks prior to the implementation of such courses.
Amr Selim Wannas, Inas Hussein Hassan
doaj   +1 more source

Sequential Voting Promotes Collective Discovery in Social Recommendation Systems

open access: yes, 2016
One goal of online social recommendation systems is to harness the wisdom of crowds in order to identify high quality content. Yet the sequential voting mechanisms that are commonly used by these systems are at odds with existing theoretical and ...
Celis, L. Elisa   +2 more
core  

Addressing the learners' needs for specific and constructive feedback [PDF]

open access: yes, 2010
This paper discusses an on-going project which proposes to make feedback to students more personal, explicit and more useful as a method of further engaging students.
Perera, Noel, Tudor, Jenna
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Higher education policy and the increase of sequential courses offer Política de ensino superior e o crescimento da oferta de cursos seqüenciais

open access: yesSemina: Ciências Sociais e Humanas, 2009
With the Law of Guidelines and Bases of the National Education no. 9.394 of December 20, 1996, the scope of courses and programs of the Brazilian Higher Education was redefined like this: sequential courses were added to the traditional ones.
Irene Domenes Zapparoli
doaj  

SkillSum: basic skills screening with personalised, computer-generated feedback [PDF]

open access: yes, 2008
We report on our experiences in developing and evaluating a system that provided formative assessment of basic skills and automatically generated personalised feedback reports for 16-19 year-old users.
Reiter, Ehud, Williams, Sandra
core   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy