Results 101 to 110 of about 214,226 (302)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Teaching of infection control in undergraduate courses in health sciences: opinion of experts

Revista Brasileira de Enfermagem
Objective: To know the perception of expert professionals in infection control and prevention on the teaching of skills for the prevention and control of infections related to health care in undergraduate courses in Health Sciences.
Aline Massaroli, Jussara Gue Martini, José Luis Medina Moya, Julia Valéria de Oliveira Vargas Bitencourt, Kenya Schmidt Reibnitz, Mariely Carmelina Bernardi   +5 more
doaj   +1 more source

A Multimedia Interactive Environment Using Program Archetypes: Divide-and-Conquer [PDF]

, 1993
As networks and distributed systems that can exploit parallel computing become more widespread, the need for ways to teach parallel programming effectively grows as well. Even though many colleges and universities provide courses on parallel programming [
Ainsworth, Paul, Kryukova, Svetlana
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Antibody responses after sequential vaccination with PCV13 and PPSV23 in patients with moderate to severe plaque psoriasis under immunosuppressive therapy

mBio
A crucial step in lowering the risk of invasive pneumococcal illness in high-risk populations, such as individuals with plaque psoriasis, is pneumococcal vaccination.
Lorena Helmer, Lukas van de Sand, Thea Wojtakowski, Mona Otte, Oliver Witzke, Wiebke Sondermann, Adalbert Krawczyk, Monika Lindemann   +7 more
doaj   +1 more source

An Unfinished Canvas: District Capacity and the Use of New State Funds for Arts Education in California [PDF]

, 2009
Questions about district leadership and capacity -- particularly in light of the new funding -- served as the impetus for this study. Through a survey of leaders in 385 districts, we assessed districts' capacity with respect to arts education, explored ...
Ashley Campell, Jennifer Bland, Katrina R. Woodworth, Nicolette Mayes   +3 more
core  

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Sequential Vaccination Against Streptococcus pneumoniae Appears as Immunologically Safe in Clinically Stable Kidney Transplant Recipients

Vaccines
Background: Vaccination against Streptococcus pneumoniae is advised for transplant recipients to reduce morbidity and mortality associated with invasive pneumococcal disease.
Monika Lindemann, Lukas van de Sand, Nils Mülling, Kim L. Völk, Ulrich W. Aufderhorst, Benjamin Wilde, Peter A. Horn, Andreas Kribben, Adalbert Krawczyk, Oliver Witzke, Falko M. Heinemann   +10 more
doaj   +1 more source

The design and implementation of an adaptive e-learning system [PDF]

, 2007
This paper describes the design and implementation of an adaptive e-learning system that provides a template for different learning materials as well as a student model that incorporates five distinct student characteristics as an aid to learning ...
Surjono, Herman Dwi
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source