Results 141 to 150 of about 154,271 (296)

Patient Selection for Spinal Cord Stimulation in Treatment of Pain: Sequential Decision-Making Model - A Narrative Review. [PDF]

J Pain Res, 2022
Goudman L, Rigoard P, Billot M, Duarte RV, Eldabe S, Moens M.   +5 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Decision Making in the Practice of Plant Disease Management

, 2007
In the practice of disease management, the challenges faced by decision makers are many and various. We outline two approaches to evidence-based decision making that have application in disease management.
Madden, L. V., Hughes, G., Van Den Bosch, F.   +2 more
core   +1 more source

A survey of multi-objective sequential decision-making

, 2013
Sequential decision-making problems with multiple objectives arise naturally in practice and pose unique challenges for research in decision-theoretic planning and learning, which has largely focused on single-objective settings.
S Whiteson (13598977), Richard Dazeley (13066251), DM Roijers (15791534), P Vamplew (13351392)   +3 more
core   +1 more source

Accelerating Probabilistic Planning Research: High-Speed Implementations of Stochastic Markov Decision Processes and Their Catalogization

IEEE Access
Probabilistic planning research, such as improvements to Monte Carlo Tree Search, is faced with two challenges. Firstly, one usually requires an algorithm’s evaluation on a variety of test problems, trying several hundred or even thousands of ...
Robin Schmocker, Alexander Dockhorn, Bodo Rosenhahn   +2 more
doaj   +1 more source

Optimal use of simplified social information in sequential decision-making. [PDF]

J R Soc Interface, 2021
Mann RP.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Novelty is not surprise: Human exploratory and adaptive behavior in sequential decision-making. [PDF]

PLoS Comput Biol, 2021
Xu HA, Modirshanechi A, Lehmann MP, Gerstner W, Herzog MH.   +4 more
europepmc   +1 more source

Individual differences in sequential decision-making

1 Abstract People differ widely in how they make decisions in uncertain environments. While many studies leverage this variability to measure differences in specific cognitive processes and parameters, the key dimension(s) of individual variability in uncertain decision-making tasks has not been identified.
Mojtaba Abbaszadeh, Erica Ozanick, Noa Magen, David Darrow, Xinyuan Yan, Nicola Grissom, Alexander B. Herman, Becket R. Ebitz   +7 more
openaire   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source