Results 71 to 80 of about 172,559 (244)
BMC MedicineBackground Although electronic alerts are being increasingly implemented in patients with acute kidney injury (AKI), their effect remains unclear. Therefore, we conducted this meta-analysis aiming at investigating their impact on the care and outcomes of
Zhangning Fu +5 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
An evaluation of the replicability of analyses using synthetic health data
Scientific ReportsSynthetic data generation is being increasingly used as a privacy preserving approach for sharing health data. In addition to protecting privacy, it is important to ensure that generated data has high utility.
Khaled El Emam +3 more
doaj +1 more source
BMC Family Practice, 2017 Background Multimorbidity is a major issue for primary care. We aimed to explore primary care professionals’ accounts of managing multimorbidity and its impact on clinical decision making and regional health care delivery.
Tim Stokes +3 more
doaj +1 more source
A Comparison of Decision Analysis and Expert Rules for Sequential Diagnosis [PDF]
, 1990 Abstract There has long been debate about the relative merits of decision theoretic methods and heuristic rule-based approaches for reasoning under uncertainty. We report an experimental comparison of the performance of the two approaches to troubleshooting, specifically to test selection for fault diagnosis.
openaire +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Manufacturing Decision Optimization Based on Sequential Testing and Cost-Benefit Analysis
Highlights in Science, Engineering and TechnologyIn the production process of enterprises, the reasonable decision of each link often affects the profits and costs of enterprises. In order to help enterprises reduce production costs, this paper uses the sequential test method to calculate the reliability of 95% and 90% of the two cases of the significance level and testing force, according to the ...
Dan Huang, Mengran Xin
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source