Results 81 to 90 of about 322,377 (296)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Sequential decision analysis for nonstationary stochastic processes [PDF]

A formulation of the problem of making decisions concerning the state of nonstationary stochastic processes is given. An optimal decision rule, for the case in which the stochastic process is independent of the decisions made, is derived.
Schaefer, B.
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

A Linear Programming Approach to Sequential Hypothesis Testing

, 2015
Under some mild Markov assumptions it is shown that the problem of designing optimal sequential tests for two simple hypotheses can be formulated as a linear program.
Fauss, Michael, Zoubir, Abdelhak M.
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Rule sets based bilevel decision model [PDF]

, 2006
Bilevel decision addresses the problem in which two levels of decision makers, each tries to optimize their individual objectives under constraints, act and react in an uncooperative, sequential manner.
He, Q, Lu, J, Shi, Z, Zhang, G, Zheng, Z
core  

Navigating Occluded Intersections with Autonomous Vehicles using Deep Reinforcement Learning

, 2018
Providing an efficient strategy to navigate safely through unsignaled intersections is a difficult task that requires determining the intent of other drivers.
Cosgun, Akansel, Fujimura, Kikuo, Isele, David, Rahimi, Reza, Subramanian, Kaushik   +4 more
core   +1 more source

Convergence of the Losses of Certain Decision Rules for the Sequential Compound Decision Problem

The Annals of Mathematical Statistics, 1964
This paper is a continuation of [8], and considers the sequential compound decision problem for the case where the component decisions are of the simple versus simple hypothesis testing type, and thus can be stated in terms of testing whether $\theta = 0$ or $\theta = 1$.
openaire   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Conditional Entropy-Based Sequential Decision-Making for AI Adoption in Manufacturing: A Reinforcement Learning Approach

Systems
Most small- and medium-sized manufacturers face challenges in adopting artificial intelligence (AI) in production systems due to limited domain expertise and challenges in making interrelated decisions.
Ga-hyun Lee, Byunghun Song, Hyun-woo Jeon   +2 more
doaj   +1 more source