Results 151 to 160 of about 312,970 (308)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Parallel sequential pattern mining on distributed system
, 2010 碩士本研究以提昇循序樣本探勘效率為目標，發展了一套結合多部電腦的分散式探勘系統。首先，由於直接以支持度預測子任務工作量並不準確，我們提出新的工作量預測方法。而後，本研究提出了一套負載平衡演算法-ADLB，結合動態與靜態分配的特點，對於任務採取分段分配，以達成負載平衡並降低通訊負擔。此外，我們也引用並改進文獻[20]中有關演算法切換的概念，以取得更大幅度效能改善。為驗證系統效能，我們結合了16部電腦進行分散式探勘，實驗結果顯示，本系統在各種不同節點數目下均具有良好加速比，顯示其具有處理大型資料之潛力 ...
郭家君; Guo, Jia-jyun
core
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Sequential Pattern Mining of Longitudinal Adverse Events After Left Ventricular Assist Device Implant. [PDF]
IEEE J Biomed Health Inform, 2020 Movahedi F +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The Sequential Initializer Tree Pattern
Proceedings of the 28th European Conference on Pattern Languages of Programs, 2023 Martin Eisemann +3 more
openaire +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Pmspm:a pincer maximal sequential pattern mining algorithm
, 2010 碩士在過去以 Apriori 為基礎的循序樣式探勘方法中，皆單純採用由下而上的方式從長度較短的頻繁樣式成長至較長的候選樣式，一直成長至沒有更長的候選樣式產生為止，因而若需探勘最長頻繁樣式時則必須將所有的頻繁樣式探勘完才可得到(所謂的最長頻繁樣式就是不屬於其它任一頻繁樣式的子樣式稱之)，造成許多不必要的運算。 本研究提出並建構一個優先探勘最長頻繁樣式之演算法PMSPM，結合由下而上以及由上而下兩種方向的探勘方式，進而早一步於由上而下的方向找出大多數的最長頻繁樣式 ...
吳鎮成; Wu, Chen-cheng
core