Results 161 to 170 of about 312,970 (308)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Hardware Architecture of Tree Structure for Real-time Progressive Sequential Pattern Mining
, 2007 傳統的循序樣式探勘演算法需要龐大的計算時間。當面臨累進式資料庫探勘時所需要的時間更多。在本論文中，我們設計了一種硬體的樹狀結構，用來解決累進式循序樣式探勘的問題。我們的演算法簡稱為HATS，運用樹狀結構代表每一個序列中的循序元素。透過管線設計，HATS可以高效率的產生循序元素。我們透過軟硬體共同設計，在可規劃邏輯閘陣列上，完成實體電路的設計與驗証。我們的實驗結果也顯示HATS不僅在隨機的測試資料中，明顯地比現有的所有循序樣式探勘演算法快速；並且對於一個在無線閘道的實際應用上表現優異 ...
Chen, Bo-Han, 陳伯翰
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Sequential pattern transformer (SPT): a generative and interpretable framework for predicting disease trajectories. [PDF]
Neural Comput ApplShalmani MA +7 more
europepmc +1 more source
Detection of Trends of Internet Traffic Using Sequential Patterns
We propose a new method of possible trend detection in the internet traffic by using sequential pattern analysis. The main steps of this method, such as the template pattern discovery in time-series data and pattern comparison and matching for sequential
Lauks, Gunārs, Jeļinskis, Jans
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Learning Sequence-to-Sequence Correspondences from Parallel Corpora
, 2003 We present an unsupervised extraction of sequence-to-sequence correspondences from parallel corpora by sequential pattern ...
Taku Kudo +4 more
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