Results 181 to 190 of about 312,970 (308)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Sequential pattern formation governed by signaling gradients. [PDF]
Phys Biol, 2016 Jörg DJ, Oates AC, Jülicher F.
europepmc +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Evaluation of relationships between onychomycosis and vascular diseases using sequential pattern mining. [PDF]
Sci Rep, 2018 Bang CH +6 more
europepmc +1 more source
A sequential pattern mining approach considering time probability
, 2010 碩士 循序樣式探勘是一門研究如何從序列資料庫裡找出頻繁循序樣式的資料探勘方法，過去的序列資料探勘方法大致可分成兩大類[2]：Apriori-like methods [7][8][9][23]和Pattern-growth methods [10][12][16][17][20]。在一個循序樣式中，兩事件間隔發生的時間機率可以提供更多資訊給決策者分析與預測關聯樣式的變化。然而先前的研究並沒有發展出能於探勘樣式的過程裡同時找出此機率的技術。因此，為了提供這樣的資訊 ...
張耕; Chang, Keng
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Applying sequential pattern mining to investigate cerebrovascular health outpatients' re-visit patterns. [PDF]
PeerJ, 2018 Ou-Yang C +4 more
europepmc +1 more source
The Progress of Creative Pattern Cutting
This paper documents the journey of several research initiatives, which focused upon creative pattern cutting. Instigated by a peer-reviewed, journal paper entitled, ‘Insufficient Allure: The Luxurious Art and Cost of Creative Pattern Cutting’ (Almond ...
Almond, Kevin, Power, Jess
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Supporting Interactive Sequential Pattern Discovery in Databases
, 2007 One of the most important data mining problems is discovery of sequential patterns. Sequential pattern mining consists in discovering all frequently occurring subsequences in a collection of data sequences.
Marek Wojciechowski
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source