Results 61 to 70 of about 11,190 (105)

Mapping CSC‐Mediated Ovarian Cancer Chemoresistance via CXCR4‐PET to Guide Precision Cisplatin Re‐Sensitization Therapy

Advanced Science, EarlyView.
CXCR4 functions as a potential cancer stem cell‐associated marker linked to chemoresistance in ovarian cancer, and an inhibitor of CXCR4, AMD3100, can enhance the cytotoxic response to cisplatin. Based on these findings, [68Ga]Ga‐Pentixafor positron emission tomography enables selective visualization of CXCR4‐high ovarian cancer, while AMD3100 combined
Lixia Feng, Simei Zhao, Zheng Wei, Wenwen Wang, Feiquan Ying, Lin Huang, Mengna Zhu, Mengqing Chen, Qiang Yang, Si Sun, Dawei Jiang, Lingling Gao, Jing Cai   +12 more
wiley   +1 more source

Metarhizium anisopliae Mitigates the Phytotoxicity of Lead and Nanoplastics on Rice by Modifying Physiological, Transcriptomic, Metabolomic Activities, and Soil Microbiome

Advanced Science, EarlyView.
Metarhizium anisopliae alleviates the phytotoxic effects of polyethylene nanoplastics (NP) and lead (Pb) in rice by decreasing Pb uptake, restoring antioxidant and hormonal equilibrium, and promoting growth. Additionally, the fungus modifies the rhizosphere microbiota, enhancing both contaminant tolerance and plant growth, thereby effectively ...
Jing Peng, Qi Yan, Muhammad Umair Hassan, Muhammad Imran, Fasih Ullah Haider, Jianfeng Liang, Xingmin Wang, Shaukat Ali   +7 more
wiley   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

Scalable Electrochemical Concrete Fabrication and Closed‐Loop Recycling

Advanced Science, EarlyView.
The electrochemical‐driven recycling strategy establishes a reversible concrete material flow by extracting Ca, Si, Al, and Fe from concrete waste and regenerating functional feedstocks. These reversed products are reassembled into new concrete, which re‐enters service and ultimately returns to waste, enabling a closed‐loop, waste‐origin, and low ...
Hanxiong Lyu, Zhenlin Li, Yang Liu, Lu Zhu, Lucen Hao, Mingxin Shi, Shipeng Zhang, Chi Sun Poon   +7 more
wiley   +1 more source

PVTree: A Sequential Pattern Mining Method for Alignment Independent Phylogeny Reconstruction. [PDF]

Genes (Basel), 2019
Kang Y, Yang X, Lin J, Ye K.
europepmc   +1 more source

Prompt Engineering Accelerates the Data‐Driven Discovery of Photocatalysts via an LLM‐Based Model Ensemble Strategy

Advanced Science, EarlyView.
This work establishes a pipeline that transforms fragmented literature into a structured database for graphitic carbon nitride photocatalyst discovery. A prompt‐engineered, cross‐model large language model ensemble automates high‐fidelity extraction, enabling interpretable machine learning to identify dominant performance descriptors. These data‐driven
Dianyuan Li, Xichen Sun, Shaohua Sun, Runzhou Wang, Miaomiao Zhang, Meng Xiao, Yue Wang, Yuezhou Zhang   +7 more
wiley   +1 more source

Finding the needle in the haystack-An interpretable sequential pattern mining method for classification problems. [PDF]

Front Big Data
Grote A, Hariharan A, Weinhardt C.
europepmc   +1 more source