Results 111 to 120 of about 10,424,890 (336)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

An Algorithm for Mining Strong Negative Fuzzy Sequential Patterns

, 2013
Many methods have been proposed for mining fuzzy sequential patterns. However, most of conventional methods only consider the occurrences of fuzzy itemsets in sequences.
Lin, Nancy P.; Hao, Wei-hua, Chen, Hung-jen; Chang, Chung-i; Chueh, Hao-en
core  

Maximal sequential patterns mining with timing constraints

, 2010
碩士循序樣式探勘的目的是從資料庫中，尋找頻繁出現且有順序的樣式，通常這些樣式會再被轉換成先前所不知道的、有用的與有價值的資訊。由於資料庫中通常存在大量且長時間的資料，因此循序樣式探勘往往需要花上大量時間。但是一般的頻繁循序樣式探勘演算法無法針對要尋找之頻繁循序樣式的時間條件加以限制，使得探勘得到的頻繁循序樣式太多且不易應用。探勘最長頻繁循序樣式雖可得到意義相同且較精簡的樣式集合，但針對長度為k之最長頻繁循序樣式探勘，不論是以PrefixSpan或是Apriori為基礎的演算法皆必須經過k個回合的探勘 ...
林師晟; Lin, Shi-cheng
core   +1 more source

Discrete Sequential Information Coding: Heteroclinic Cognitive Dynamics

Frontiers in Computational Neuroscience, 2018
Discrete sequential information coding is a key mechanism that transforms complex cognitive brain activity into a low-dimensional dynamical process based on the sequential switching among finite numbers of patterns.
Mikhail I. Rabinovich, Pablo Varona
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mining sequential patterns with flexible constraints from MOOC data. [PDF]

Appl Intell (Dordr), 2022
Song W, Ye W, Fournier-Viger P.
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Efficacy of different sequential patterns after crizotinib progression in advanced anaplastic lymphoma kinase-positive non-small cell lung cancer. [PDF]

Thorac Cancer, 2022
Ma X, Yang S, Zhang K, Xu J, Lv P, Gao H, Qin H, Wang H, Liu X.   +8 more
europepmc   +1 more source

Pattern-Wise Transparent Sequential Recommendation

IEEE Transactions on Knowledge and Data Engineering
This paper has been accepted by IEEE ...
Kun Ma, Cong Xu 0005, Zeyuan Chen, Wei Zhang 0056   +3 more
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source