Results 91 to 100 of about 310,714 (306)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Discovering Spatially Interesting Patterns in Big Geo-Referenced Sequential Databases

IEEE Access
Geo referenced time series is a cornerstone in spatiotemporal data analysis, revealing invaluable patterns that drive socio-economic development. Previous studies have modeled these series as transactional databases.
Vanitha Kattumuri, Rage Uday Kiran, Shota Suzuki   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Analysis of digital footprints associated with cybersecurity behavior patterns of users of University Information and Education Systems [PDF]

International Journal of Electronics and Telecommunications
The analysis of digital footprints (DF) related to the cybersecurity (cyber risk) user behavior of university information and education systems (UIES) involves the study and evaluation of various aspects of activity in the systems.
Valerii Lakhno, Nurgazy Kurbaiyazov, Miroslav Lakhno, Olena Kryvoruchko, Alona Desiatko, Svitlana Tsiutsiura, Mykola Tsiutsiura   +6 more
doaj   +1 more source

Non-redundant sequential association rule mining based on closed sequential patterns

, 2010
In many applications, e.g., bioinformatics, web access traces, system utilisation logs, etc., the data is naturally in the form of sequences. People have taken great interest in analysing the sequential data and finding the inherent characteristics or ...
Zang, Hao
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Privately vertically mining of sequential patterns based on differential privacy with high efficiency and utility. [PDF]

Sci Rep, 2023
Liang W, Zhang W, Liang S, Yuan C.
europepmc   +1 more source

An Algorithm for Mining Strong Negative Fuzzy Sequential Patterns

, 2013
Many methods have been proposed for mining fuzzy sequential patterns. However, most of conventional methods only consider the occurrences of fuzzy itemsets in sequences.
Lin, Nancy P.; Hao, Wei-hua, Chen, Hung-jen; Chang, Chung-i; Chueh, Hao-en
core  

Sequential Patterns Postprocessing for Structural Relation Patterns Mining

, 2010
Sequential patterns mining is an important data-mining technique used to identify frequently observed sequential occurrence of items across ordered transactions over time. It has been extensively studied in the literature, and there exists a diversity of
Weiru Chen, Jing Lu, Osei Adjei, Malcolm Keech   +3 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source