Results 81 to 90 of about 310,714 (306)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Mining fuzzy time sequential patterns
, 2010 碩士 挖掘序列型樣是資料挖掘中一項重要的技術，主要用於找出序列資料庫中的頻繁子序列。一般挖掘序列型樣的演算法大多能正確找出頻繁項目集之間的發生先後順序，但對於其出現前後的間隔時間卻無法加以描述。 為了有效解決此一問題，本研究結合階層式分群法與模糊數的概念，提出一個挖掘模糊時間序列型樣的演算法，不僅可以挖掘出序列資料庫中所有頻繁項目及其出現的順序關係，更可將其出現的間隔時間以合理的方式表示。An important task of sequential patterns mining is to ...
廖珮妤; Liao, Pei-yu
core
Incremental mining of temporal patterns in interval-based database
, 2016 In several real-life applications, sequence databases, in general, are updated incrementally with time. Some discovered sequential patterns may be invalidated and some new ones may be introduced by the evolution of the database.
Hui, Lin; Chen, Yi-Cheng; Weng, Julia Tzu-Ya; Lee, Suh-Yin
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Applied Sciences, 2019 Medication is designed to cure diseases, but serious risks can arise from severe adverse drug reactions (ADRs). ADRs can lead to emergency room visits and hospitalization, straining healthcare resources and, thus, they have strong implications for public
Chao Ou-Yang +3 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Can post-error dynamics explain sequential reaction time patterns?
Frontiers in Psychology, 2012 We investigate human error dynamics in sequential two-alternative choice tasks. When subjects repeatedly discriminate between two stimuli, their error rates and mean reaction times (RTs) systematically depend on prior sequences of stimuli.
Stephanie eGoldfarb +9 more
doaj +1 more source
Detecting multineuronal temporal patterns in parallel spike trains
, 2012 We present a non-parametric and computationally efficient method that detects spatiotemporal firing patterns and pattern sequences in parallel spike trains and tests whether the observed numbers of repeating patterns and sequences on a given timescale ...
Kai S. Gansel +6 more
core +1 more source