Results 121 to 130 of about 310,714 (306)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Incremental Mining of Closed Sequential Patterns in Multiple Data Streams
, 2012 Sequential pattern mining searches for the relative sequence of events, allowing users to make predictions on discovered sequential patterns. Due to drastically advanced information technology over recent years, data have rapidly changed, growth in data ...
Yang, Shih-yang; Chao, Ching-ming; Chen, Po-zung; Sun, Chu-hao
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Visual analysis of oceanic data for marine ecosystems
Ecological InformaticsWe present a data visualization approach that allows users to interactively analyse sequential movement patterns and automatically extract rules for marine animal behaviour.
Vegu Shree Rama Kamal Kumar +1 more
doaj +1 more source
The periodical intervals analysis on sequential patterns
, 2010 碩士在處理大量交易資料分析時，我們往往透過關聯式法則(Asso- ciation Rules)分析所有交易項目的搭配銷售組合，並使用序列型樣(Sequential Patterns)分析顧客先後交易習性，但我們運用在產品推薦系統上僅能利用序列型樣得知產品先後購買順序，卻無法得知先後購買產品的間隔時間，以致無法在所有顯著序列資訊的產品之間根據適當時間給予最有利的產品行銷。 本篇論文提出一套用來分析序列型樣對於時間間隔是否潛在週期之演算法，首先我們提出PDT/PDM演算法用來尋找曲線的週期性分布 ...
李宜靝; Lee, Yi-tian
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Graph-based discovery of ontology change patterns [PDF]
, 2011 Ontologies can support a variety of purposes, ranging from capturing conceptual knowledge to the organisation of digital content and information. However, information systems are always subject to change and ontology change management can pose challenges.
Abgaz, Yalemisew +3 more
core
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Maintenance of discovered sequential patterns for record deletion
, 2009 [[abstract]]Mining sequential patterns from temporal transaction databases attempts to find customer behavior models and to assist managers in making correct and effective decisions.
C. Y. Wang; T. P. Hong ; S. S. Tseng
core
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source