Results 141 to 150 of about 310,714 (306)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Hiding Fuzzy Sequential Patterns by a Multi-Objective Scheme

open access: yesInternational Journal of Information and Communication Technology Research, 2016
Improvements in technology have led to generating and mining huge amounts of data. Sequence mining is a research area of data mining that aims to extract useful knowledge from raw databases.
Olya Sadat Behbahani   +2 more
doaj  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Mining high utility sequential patterns [PDF]

open access: yes, 2015
University of Technology Sydney. Faculty of Engineering and Information Technology.Sequential pattern mining refers to the identification of frequent subsequences in sequence databases as patterns.
Yin, J
core  

Parallel mining of closed sequential patterns

open access: yes, 2005
Discovery of sequential patterns is an essential data mining task with broad applications. Among several variations of sequential patterns, closed sequential pattern is the most useful one since it retains all the information of the complete pattern set ...
Jiawei Han, David Padua, Shengnan Cong
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Biomechanical effects of aligner trimline design and intrusion protocol on mandibular anterior teeth: a finite element study

open access: yesBMC Oral Health
Objective This study employed finite element analysis to evaluate the biomechanical effects of different aligner trimline designs (scalloped vs. high trimline) and intrusion methods (sequential vs. simultaneous) during mandibular anterior teeth intrusion.
Rugan Su, Jun Sun, Song Li, Wei Wang
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Sequential Patterns Mining

open access: yes, 2008
AND DUMITRU RĂDOIU Abstract. This paper presents a novel data mining technique, known as Post Sequential Patterns Mining. The technique can be used to discover structural patterns that are composed of sequential patterns, branch patterns or iterative ...
Călin Enăchescu   +4 more
core  

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