Results 111 to 120 of about 26,362,948 (329)

Sequential control of time series by functionals of kernel-weighted empirical processes under local alternatives [PDF]

Motivated in part by applications in model selection in statistical genetics and sequential monitoring of financial data, we study an empirical process framework for a class of stopping rules which rely on kernel-weighted averages of past data.
Steland, Ansgar
core  

Trial Sequential Analysis for dichotomous outcomes – a practical guide for systematic review protocols

BMC Medical Research Methodology
Background Trial Sequential Analysis (TSA) is a statistical method to control random errors in systematic reviews with meta-analyses of randomised clinical trials.
Sophie Juul, Christian Gunge Riberholt, Markus Harboe Olsen, Joachim Birch Milan, Sigurlaug Hanna Hafliðadóttir, Jeppe Houmann Svanholm, Elisabeth Buck Pedersen, Charles Chin Han Lew, Mark Aninakwah Asante, Johanne Pereira Ribeiro, Vibeke Wagner, Buddheera W. M. B. Kumburegama, Zheng-Yii Lee, Julie Perrine Schaug, Christina Madsen, Christian Gluud   +15 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Other title: Office of Criminal Justice Services research brief; Other title: Bulletin of the Ohio Statistical Analysis Center

, 2012
Irregular; Began with: Volume 1, Issue 1 (April 2012).; Subtitle varies: "Quarterly bulletin of the Ohio Statistical Analysis Center," April 2012; "A bulletin of the Ohio Statistical Analysis Center," September 2012-; Harvested from the web on 1/6 ...
Ohio Statistical Analysis Center,
core  

An effective method for the explicit solution of sequential problems on the real line

, 2017
A general method for solving optimal stopping problems for continuous-time Markov processes on the real line is developed. The basic idea is to first study an auxiliary problem for the two-dimensional process consisting of the underlying Markov process ...
Sören Christensen, Christensen, Sören,
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Detection method for selfish routes based on the sequential probability ratio test

Dianxin kexue, 2016
According to a network model based on the sequential probability ratio test（SPRT），one detection method of selfish routes with respect to the routing functionality in wireless sensor network was developed.Through the analysis of the observed sample values
Qi WANG, Qingping WANG, Huaixing WANG, Zheng’an XIAO   +3 more
doaj   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Design of Morlet wavelet neural networks integrated with sequential quadratic programming to analyze the dynamics of Ebola virus disease

Results in Engineering
Ebola virus disease is caused by a virus that originates in flying foxes, or fruit bats. These bats may spread the virus to humans. The proposed model partitions the infected population into unaware and aware, and has a hospitalized compartment.
Asifa Ashraf, Abaid Ur Rehman Virk, Umar Ishtiaq, Ahmed Samy Mohamed Elwahsh, Ioan-Lucian Popa   +4 more
doaj   +1 more source