Results 121 to 130 of about 26,362,948 (329)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

CORRESPONDENCE ANALYSIS ON STATISTICAL LITERACY AND GENDER: EMBEDDING E-CAMPUS PLATFORM WITH RANDOM ASSIGNMENT OF MATCHED SUBJECT IN EXPLANATORY ANALYSIS

Barekeng
This study aims to evaluate the embedding of e-campus platforms during the pandemic in dealing with gender disparities in statistical literacy and shed light on the association structure between statistical literacy and gender disparities.
Karunia Eka Lestari, Risnawita Risnawita, Mokhammad Ridwan Yudhanegara, Edwin Setiawan Nugraha, Sisilia Sylviani   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

SMCTC: Sequential Monte Carlo in C++ [PDF]

Sequential Monte Carlo methods are a very general class of Monte Carlo methods for sampling from sequences of distributions. Simple examples of these algorithms are used very widely in the tracking and signal processing literature.
Adam M. Johansen
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Statistical analysis of hydroclimatic time series: Uncertainty and insights

, 2007
Today, hydrologic research and modeling depends largely on climatological inputs, whose physical and statistical behavior are the subject of many debates in the scientific community. A relevant ongoing discussion is focused on long-term persistence (LTP),
Demetris Koutsoyiannis, Alberto Montanari, Koutsoyiannis D, Koutsoyiannis, D, Montanari, A, MONTANARI, ALBERTO   +5 more
core   +1 more source

Inference in group sequential designs with causal mechanisms: implications for power and mediation analysis

BMC Medical Research Methodology
Background Group sequential designs are increasingly employed to allow trials to stop early with statistical rigor. While existing work focuses on intention-to-treat effect on clinical endpoints, the properties of mediation analysis (commonly conducted ...
Kim May Lee, Richard Emsley
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Sequential statistical hypotheses testing for discrete random data with block structure

Журнал Белорусского государственного университета: Математика, информатика
An important mathematical problem of computer data analysis – the problem of sequential statistical testing of simple hypotheses on probability distributions of discrete random data with a block structure – is considered.
Alexey Yu. Kharin
doaj  

Identification of Critical Thinking Skills in Physics Based on Students Thinking Style in Class XI SMAN 5 Wajo

JPFT (Jurnal Pendidikan Fisika dan Teknologi)
This research is a quantitative study which aims to determine the description of critical thinking abilities in physics in terms of students' thinking styles.
Rosdiana Rosdiana, Usman Usman, Mutahharah Hasyim, Trisno Setiawan   +3 more
doaj   +1 more source