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Sequential analysis and its applications to neuromorphic engineering [PDF]

Frontiers in Neuroscience
Introduction:Neuromorphic circuits operate by comparing fluctuating signals to thresholds. This operation underpins sensing and computation in both neuromorphic architectures and biological nervous systems.
Shivaram Mani, Saeed Afshar, Travis Monk
doaj   +2 more sources

Statistical Sequential Experimentation: Preliminary Mixed Factorial Design, I-Optimal Mixture Design Then Finally Novel Design Space Expansion for Optimization of Tazarotene Cubosomes

International Journal of Nanomedicine, 2022
Doaa Hegazy, Randa Tag, Basant Ahmed Habib Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, EgyptCorrespondence: Doaa Hegazy, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy ...
Hegazy D, Tag R, Habib BA
doaj   +3 more sources

Inference in group sequential designs with causal mechanisms: implications for power and mediation analysis [PDF]

BMC Medical Research Methodology
Background Group sequential designs are increasingly employed to allow trials to stop early with statistical rigor. While existing work focuses on intention-to-treat effect on clinical endpoints, the properties of mediation analysis (commonly conducted ...
Kim May Lee, Richard Emsley
doaj   +2 more sources

No relevant differences in conditioned pain modulation effects between parallel and sequential test design. A cross-sectional observational study [PDF]

PeerJ, 2021
Background Conditioned pain modulation (CPM) is measured by comparing pain induced by a test stimulus with pain induced by the same test stimulus, either during (parallel design) or after (sequential design) the conditioning stimulus.
Roland R. Reezigt, Sjoerd C. Kielstra, Michel W. Coppieters, Gwendolyne G.M. Scholten-Peeters   +3 more
doaj   +2 more sources

Digital Triplet: A Sequential Methodology for Digital Twin Learning

Mathematics, 2023
A digital twin is a simulator of a physical system, which is built upon a series of models and computer programs with real-time data (from sensors or devices).
Xueru Zhang, Dennis K. J. Lin, Lin Wang
doaj   +1 more source

Permutation-based group sequential analyses for cognitive neuroscience

NeuroImage, 2023
Cognitive neuroscientists have been grappling with two related experimental design problems. First, the complexity of neuroimaging data (e.g. often hundreds of thousands of correlated measurements) and analysis pipelines demands bespoke, non-parametric ...
John P. Veillette, Letitia Ho, Howard C. Nusbaum   +2 more
doaj   +1 more source

A systematic review of randomised controlled trials with adaptive and traditional group sequential designs – applications in cardiovascular clinical trials

BMC Medical Research Methodology, 2023
Background Trial design plays a key role in clinical trials. Traditional group sequential design has been used in cardiovascular clinical trials over decades as the trials can potentially be stopped early, therefore, it can reduce pre-planned sample size
Jufen Zhang, Christy Saju
doaj   +1 more source

Bayesian and frequentist approaches to sequential monitoring for futility in oncology basket trials: A comparison of Simon's two-stage design and Bayesian predictive probability monitoring with information sharing across baskets.

PLoS ONE, 2022
This article discusses and compares statistical designs of basket trial, from both frequentist and Bayesian perspectives. Baskets trials are used in oncology to study interventions that are developed to target a specific feature (often genetic alteration
Alexander Kaizer, Emily Zabor, Lei Nie, Brian Hobbs   +3 more
doaj   +1 more source

Adherence and treatment patterns of disease-specific drugs among patients with pulmonary arterial hypertension: A nationwide, new-user cohort study

Frontiers in Pharmacology, 2023
Background: Pulmonary arterial hypertension (PAH) is an incurable pulmonary disease that might result in right heart failure and death. Treatment guidelines recommend upfront or sequential combination therapy for patients with PAH.
Cheng-Yu Tsai, Chuan-Wei Shen, Hsuan-Lin Lai, Chung-Yu Chen, Chung-Yu Chen, Chung-Yu Chen   +5 more
doaj   +1 more source

Exploiting Complexity Information for Brain Activation Detection. [PDF]

PLoS ONE, 2016
We present a complexity-based approach for the analysis of fMRI time series, in which sample entropy (SampEn) is introduced as a quantification of the voxel complexity.
Yan Zhang, Jiali Liang, Qiang Lin, Zhenghui Hu   +3 more
doaj   +1 more source