Results 31 to 40 of about 755,585 (280)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Learned multi-stability in mechanical networks

, 2019
We contrast the distinct frameworks of materials design and physical learning in creating elastic networks with desired stable states. In design, the desired states are specified in advance and material parameters can be optimized on a computer with this
Murugan, Arvind, Pinson, Matthew B., Stern, Menachem   +2 more
core   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Sequential design of computer experiments for the estimation of a probability of failure [PDF]

, 2012
This paper deals with the problem of estimating the volume of the excursion set of a function $f:\mathbb{R}^d \to \mathbb{R}$ above a given threshold, under a probability measure on $\mathbb{R}^d$ that is assumed to be known.
A. Arnaud, A. Borri, A. O’Hagan, A.M. Yaglom, B. Echard, B. Echard, B.J. Bichon, C. Currin, C.G. Bucher, D. Ginsbourger, D.A. Berry, D.P. Bertsekas, D.R. Jones, David Ginsbourger, E. Parzen, E. Vazquez, E. Vazquez, E.M. Vestrup, Emmanuel Vazquez, F. Deheeger, F. Fleuret, G.E.P. Box, G.S. Kimeldorf, H. Pradlwarter, H.J. Kushner, J. Mockus, J. Mockus, J. Oakley, J. Oakley, J. Sacks, J. Villemonteix, J.E. Hurtado, J.E. Hurtado, J.L. Loeppky, J.P. Chilès, Julien Bect, L. Schueremans, Ling Li, M. Kennedy, M.J. Bayarri, M.L. Stein, M.R. Rajashekhar, M.S. Handcock, P. Bjerager, P. Ranjan, P.I. Frazier, R. Paulo, R. Rubinstein, S.K. Au, T.J. Santner, V. Picheny, Victor Picheny, W.H. Press, W.J. Welch   +53 more
core   +3 more sources

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Implementing online interventions in ICare: A biostatistical perspective

Internet Interventions, 2019
The implementation of research studies is a highly complex process. All decisions with respect to the study design impact the statistical analyses and interpretation of the results.
Dennis Görlich, Andreas Faldum
doaj   +1 more source

In-service mathematics teachers’ knowledge of differentiated instruction

Journal of Research and Advances in Mathematics Education, 2022
This study sought to investigate in-service mathematics teachers’ knowledge of differentiated instruction in junior high schools in Tano South Municipality of Ghana. The study adopted an explanatory sequential mixed method design. We employed a sample of
Patrick Kyeremeh, Nixon Saba Adzifome, Emmanuel Kojo Amoah   +2 more
doaj   +1 more source

Spectral Efficiency and Energy Efficiency Tradeoff in Massive MIMO Downlink Transmission with Statistical CSIT

, 2020
As a key technology for future wireless networks, massive multiple-input multiple-output (MIMO) can significantly improve the energy efficiency (EE) and spectral efficiency (SE), and the performance is highly dependant on the degree of the available ...
Gao, Xiqi, Wang, Wenjin, Xiong, Jiayuan, You, Li, Zappone, Alessio   +4 more
core   +1 more source

Sequential Design with Derived Win Statistics

The Win Ratio has gained significant traction in cardiovascular trials as a novel method for analyzing composite endpoints (Pocock and others, 2012). Compared with conventional approaches based on time to the first event, the Win Ratio accommodates the varying priorities and types of outcomes among components, potentially offering greater statistical ...
Zhang, Baoshan, Wu, Yuan
openaire   +2 more sources