Results 31 to 40 of about 12,245,503 (251)

Statistical Design of Sequential Decision Making Algorithms

, 2022
Sequential decision-making is a fundamental class of problem that motivates algorithm designs of online machine learning and reinforcement learning. Arguably, the resulting online algorithms have supported modern online service industries for their data ...
Wang, Chi-hua
core   +3 more sources

Sequential boundaries approach in clinical trials with unequal allocation ratios

BMC Medical Research Methodology, 2006
Background In clinical trials, both unequal randomization design and sequential analyses have ethical and economic advantages. In the single-stage-design (SSD), however, if the sample size is not adjusted based on unequal randomization, the power of the ...
Ayatollahi Seyyed, Jafari Peyman, Behboodian Javad   +2 more
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

A Bayesian Adaptive Platform Trial for Evaluating Mechanical Ventilation Strategies Using Patient-Centered Endpoints in Heterogeneous ICU Populations: SMART-VENT

Epidemiology, Biostatistics and Public Health
Introduction Acute respiratory distress syndrome (ARDS) and acute respiratory failure exhibit profound heterogeneity in clinical presentation, lung mechanics, and individual response to intensive care treatments.
Domenico Iervolino, Pasquale Dolce, Vittorio Scisciola, Pietro Fusco , Michele Francesco Di Tolla, Mohd Rashid Khan, Savino Spadaro, Danila Azzolina   +7 more
doaj   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

Sequential fixed width confidence intervals [PDF]

, 2000
We consider the problem of constructing confidence intervals of fixed width d and confidence level γ for the success probability p in Bernoulli trials.
Asparouhov, Tihomir Zlatev
core   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

A Capability-Driven Sequential Optimization Framework for Electrical Machines Under Manufacturing Uncertainty

International Transactions on Electrical Energy Systems
This paper presents a capability-driven sequential optimization framework for the robust design of electrical machines under manufacturing uncertainty.
Chiweta E. Abunike, Ogbonnaya I. Okoro, Sumeet S. Aphale   +2 more
doaj   +1 more source

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

Design Rework Prediction in Concurrent Design Environment: Current Trends and Future Research Directions [PDF]

, 2009
Organised by: Cranfield UniversityThis paper aims to present state-of-the-art and formulate future research areas on design rework in concurrent design environment. Related literatures are analysed to extract the key factors which impact design rework.
Shehab, Essam, Roy, Rajkumar, Arundachawat, Panumas, Al-Ashaab, Ahmed   +3 more
core   +5 more sources