Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Design selection criteria for discrimination between nested models for binomial data [PDF]
, 2006 The aim of an experiment is often to enable discrimination between competing forms for a response model. We consider this problem when there are two competing generalized linear models (GLMs) for a binomial response.
Lewis, S. M. +3 more
core
Implementing online interventions in ICare: A biostatistical perspective
Internet Interventions, 2019 The implementation of research studies is a highly complex process. All decisions with respect to the study design impact the statistical analyses and interpretation of the results.
Dennis Görlich, Andreas Faldum
doaj +1 more source
In-service mathematics teachers’ knowledge of differentiated instruction
Journal of Research and Advances in Mathematics Education, 2022 This study sought to investigate in-service mathematics teachers’ knowledge of differentiated instruction in junior high schools in Tano South Municipality of Ghana. The study adopted an explanatory sequential mixed method design. We employed a sample of
Patrick Kyeremeh +2 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
On optimality of kernels for approximate Bayesian computation using sequential Monte Carlo [PDF]
, 2011 Approximate Bayesian computation (ABC) has gained popularity over the past few years for the analysis of complex models arising in population genetics, epidemiology and system biology.
Barnes, C +7 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Simulation Experiments in Practice: Statistical Design and Regression Analysis [PDF]
In practice, simulation analysts often change only one factor at a time, and use graphical analysis of the resulting Input/Output (I/O) data. The goal of this article is to change these traditional, naïve methods of design and analysis, because ...
Kleijnen, J.P.C.
core +4 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Joint Estimation and Decoding of Space-Time Trellis Codes
EURASIP Journal on Advances in Signal Processing, 2002 We explore the possibility of using an emerging tool in statistical signal processing, sequential importance sampling (SIS), for joint estimation and decoding of space-time trellis codes (STTC).
Zhang Jianqiu, Djurić Petar M
doaj +1 more source