Results 61 to 70 of about 755,585 (280)

Sliced rotated sphere packing designs

, 2017
Space-filling designs are popular choices for computer experiments. A sliced design is a design that can be partitioned into several subdesigns. We propose a new type of sliced space-filling design called sliced rotated sphere packing designs. Their full
He, Xu
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Optimization of Process Parameters by Statistical Experimental Designs for the Production of Naringinase Enzyme by Marine Fungi

International Journal of Chemical Engineering, 2014
Naringinase has attracted a great deal of attention in recent years due to its hydrolytic activities which include the production of rhamnose and prunin and debittering of citrus fruit juices.
Abeer Nasr Shehata, Abeer Abas Abd El Aty   +1 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Approximate cost-efficient sequential designs for binary response models with application to switching measurements

, 2008
The efficiency of an experimental design is ultimately measured in terms of time and resources needed for the experiment. Optimal sequential (multi-stage) design is studied in the situation where each stage involves a fixed cost. The problem is motivated
Abdelbasit, Biedermann, Birge, Caldeira, Chaloner, Chaudhuri, Chaudhuri, Dixon, Dorta-Guerra, Dror, Ford, Gezmu, Hastie, Ivanova, Josephson, Juha Karvanen, Karvanen, Karvanen, Karvanen, Mathew, McCullagh, McLeish, Minkin, Pekola, Robbins, Sitter, Sitter, Sitter, Tekle, Woods, Wu   +30 more
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

An Exploratory Sequential Mixed Methods Approach to Understanding Researchers’ Data Management Practices at UVM: Integrated Findings to Develop Research Data Services

Journal of eScience Librarianship, 2017
This is the third in a series of articles reporting on a study of researcher data management practices and data services at the University of Vermont.
Elizabeth A. Berman
doaj   +1 more source

Finite sample performance of sequential designs for model identification [PDF]

Classical regression analysis is usually performed in two steps. In a first step an appropriate model is identified to describe the data generating process and in a second step statistical inference is performed in the identified model.
Dette, Holger, Kwiecien, Robert
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Two-stage re-estimation adaptive design: a simulation study

Epidemiology, Biostatistics and Public Health, 2022
  Background: adaptive clinical trial design has been proposed as a promising new approach to improve the drug discovery process. Among the many options available, adaptive sample size re-estimation is of great interest mainly because of its ...
Francesca Galli, Luigi Mariani
doaj