Results 81 to 90 of about 268,793 (310)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Bayes sequential design procedures : theory and applications [PDF]
, 1978 This thesis considers the problem of the sequential design of experiments from a Bayesian standpoint. Viewed as a sequential decision problem with a choice of experiments at each stage, the Bayes (i.e.
Edwards, H. P.
core +1 more source
Adaptive experimental designs have gained popularity in clinical trials and online experiments. Unlike traditional, fixed experimental designs, adaptive designs can dynamically adjust treatment randomization probabilities and other design features in response to data accumulated sequentially during the experiment.
Zhang, Wenxin, van der Laan, Mark
openaire +2 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Modeling inconsistencies in people's preferential choices with sequential sampling models [PDF]
, 2014 People are faced with hundreds of decisions every day, of which many involve choices between multi-attribute options. To study how people evaluate these options, different approaches have been suggested.
Berkowitsch, Nicolas A.J.
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Ingeniería e Investigación, 2010 Metalworking companies represent one of the strategic sectors in the regional economy of the Caldas department in Colombia; in fact, this sector is involved in 31% of the department’s industrial establishments and 29% of industrial employment according ...
Jaime Alberto Giraldo García +2 more
doaj
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Optimal Sequential Investigation Rules in Competition Law [PDF]
Although both in US antitrust and European competition law there is a clear evolution to a much broader application of "rule of reason" (instead of per-se rules), there is also an increasing awareness of the problems of a case-by-case approach.
Jürgen-Peter Kretschmer +2 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Sequential control of time series by functionals of kernel-weighted empirical processes under local alternatives [PDF]
Motivated in part by applications in model selection in statistical genetics and sequential monitoring of financial data, we study an empirical process framework for a class of stopping rules which rely on kernel-weighted averages of past data.
Steland, Ansgar
core