Results 91 to 100 of about 268,793 (310)

DTR: An R Package for Estimation and Comparison of Survival Outcomes of Dynamic Treatment

Journal of Statistical Software, 2015
Sequentially randomized designs, more recently known as sequential multiple assignment randomized trial (SMART) designs, are widely used in biomedical research, particularly in clinical trials, to assess and compare the effects of various treatment ...
Xinyu Tang, Maria Melguizo
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Sequential License Buyback Auctions: An Experimental Analysis [PDF]

Fisheries managers use licenses as a method of capping the size of a fishing industry, but as management goals change and the size of fishery stocks fluctuate, managers may be faced with the decision to buy back licenses.
Freeman, Matthew A., Woodward, Richard T.   +1 more
core   +1 more source

D-optimal designs for Poisson regression models [PDF]

, 2008
We consider the problem of finding an optimal design under a Poisson regression model with a log link, any number of independent variables and an additive linear predictor.
Lewis, S. M., Woods, D. C., Eccleston, J. A., Woods, D.C., Eccleston, J.A., Lewis, S.M., Russell, K.G., Russell, K. G.   +7 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Optimization techniques with knowledge based control in ship concept design [PDF]

, 1990
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.An integrated computational approach to Ship Concept Design using optimization techniques and a knowledge base to control the optimization process has been ...
Schachter, Richard David, Schachter, R.D
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Software for Implementing the Sequential Elimination of Level Combinations Algorithm [PDF]

Genetic algorithms (GAs) are a popular technology to search for an optimum in a large search space. Using new concepts of forbidden array and weighted mutation, Mandal, Wu, and Johnson (2006) used elements of GAs to introduce a new global optimization ...
Abhyuday Mandal, Tan Ding, Kjell Johnson
core   +1 more source

Robustness of Triple Sampling Inference Procedures to Underlying Distributions [PDF]

, 2010
In this study, the sensitivity of the sequential normal-based triple sampling procedure for estimatingthe population mean to departures from normality is discussed.
Yousef, Ali Saleh Ali
core