Results 71 to 80 of about 755,585 (280)

Antipyretic therapy in critically ill patients with established sepsis: a trial sequential analysis.

PLoS ONE, 2015
Background and objectiveantipyretic therapy for patients with sepsis has long been debated. The present study aimed to explore the beneficial effect of antipyretic therapy for ICU patients with sepsis.Designsystematic review and trial sequential analysis
Zhongheng Zhang
doaj   +1 more source

Estimation and Testing in Targeted Group Sequential Covariate-adjusted Randomized Clinical Trials [PDF]

, 2011
This article is devoted to the construction and asymptotic study of adaptive group sequential covariate-adjusted randomized clinical trials analyzed through the prism of the semiparametric methodology of targeted maximum likelihood estimation (TMLE).
Chambaz, Antoine, van der Laan, Mark J.
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Two-stage re-estimation adaptive design: a simulation study

Epidemiology, Biostatistics and Public Health, 2013
Background: adaptive clinical trial design has been proposed as a promising new approach to improve the drug discovery process. Among the many options available, adaptive sample size re-estimation is of great interest mainly because of its ability to ...
Francesca Galli, Luigi Mariani
doaj   +1 more source

Group sequential designs for negative binomial outcomes

, 2018
Count data and recurrent events in clinical trials, such as the number of lesions in magnetic resonance imaging in multiple sclerosis, the number of relapses in multiple sclerosis, the number of hospitalizations in heart failure, and the number of ...
Friede, Tim, Glimm, Ekkehard, Mütze, Tobias, Schmidli, Heinz   +3 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Safety and Efficacy of miltefosine alone and in combination with sodium stibogluconate and liposomal amphotericin B for the treatment of primary visceral leishmaniasis in East Africa: study protocol for a randomized controlled trial

Trials, 2011
Background Treatment options for Visceral Leishmaniasis (VL) in East Africa are far from satisfactory due to cost, toxicity, prolonged treatment duration or emergence of parasite resistance.
Kinoti Dedan, Njoroge Njenga, Wasunna Monique, Abuzaid Abuzaid A, Younis Brima M, Khalil Eltahir AG, Edwards Tansy, Alexander Neal, Omollo Raymond, Kirigi George, Dorlo Thomas PC, Ellis Sally, Balasegaram Manica, Musa Ahmed M   +13 more
doaj   +1 more source

Sequential control of time series by functionals of kernel-weighted empirical processes under local alternatives [PDF]

Motivated in part by applications in model selection in statistical genetics and sequential monitoring of financial data, we study an empirical process framework for a class of stopping rules which rely on kernel-weighted averages of past data.
Steland, Ansgar
core  

A new specification of generalized linear models for categorical data [PDF]

, 2014
Regression models for categorical data are specified in heterogeneous ways. We propose to unify the specification of such models. This allows us to define the family of reference models for nominal data.
Guédon, Yann, Peyhardi, Jean, Trottier, Catherine   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source