Results 71 to 80 of about 268,793 (310)

Sensitivity analysis and related analysis: A survey of statistical techniques [PDF]

This paper reviews the state of the art in five related types of analysis, namely (i) sensitivity or what-if analysis, (ii) uncertainty or risk analysis, (iii) screening, (iv) validation, and (v) optimization. The main question is: when should which type
Kleijnen, J.P.C.
core   +1 more source

Two-stage re-estimation adaptive design: a simulation study

Epidemiology, Biostatistics and Public Health, 2022
  Background: adaptive clinical trial design has been proposed as a promising new approach to improve the drug discovery process. Among the many options available, adaptive sample size re-estimation is of great interest mainly because of its ...
Francesca Galli, Luigi Mariani
doaj  

Antipyretic therapy in critically ill patients with established sepsis: a trial sequential analysis.

PLoS ONE, 2015
Background and objectiveantipyretic therapy for patients with sepsis has long been debated. The present study aimed to explore the beneficial effect of antipyretic therapy for ICU patients with sepsis.Designsystematic review and trial sequential analysis
Zhongheng Zhang
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Inference in group sequential designs with causal mechanisms: implications for power and mediation analysis

BMC Medical Research Methodology
Background Group sequential designs are increasingly employed to allow trials to stop early with statistical rigor. While existing work focuses on intention-to-treat effect on clinical endpoints, the properties of mediation analysis (commonly conducted ...
Kim May Lee, Richard Emsley
doaj   +1 more source

Two-stage re-estimation adaptive design: a simulation study

Epidemiology, Biostatistics and Public Health, 2013
Background: adaptive clinical trial design has been proposed as a promising new approach to improve the drug discovery process. Among the many options available, adaptive sample size re-estimation is of great interest mainly because of its ability to ...
Francesca Galli, Luigi Mariani
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Statistical characterization for timing sign-off : from silicon to design and back to silicon [PDF]

, 2009
textWith aggressive technology scaling, within-die random variations are becoming the most dominant source of process variations. Gate-level statistical static timing is becoming a widely accepted approach as an alternative to static timing analysis ...
Sundareswaran, Savithri
core  

Safety and Efficacy of miltefosine alone and in combination with sodium stibogluconate and liposomal amphotericin B for the treatment of primary visceral leishmaniasis in East Africa: study protocol for a randomized controlled trial

Trials, 2011
Background Treatment options for Visceral Leishmaniasis (VL) in East Africa are far from satisfactory due to cost, toxicity, prolonged treatment duration or emergence of parasite resistance.
Kinoti Dedan, Njoroge Njenga, Wasunna Monique, Abuzaid Abuzaid A, Younis Brima M, Khalil Eltahir AG, Edwards Tansy, Alexander Neal, Omollo Raymond, Kirigi George, Dorlo Thomas PC, Ellis Sally, Balasegaram Manica, Musa Ahmed M   +13 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source