Results 71 to 80 of about 12,245,503 (251)
Journal of eScience Librarianship, 2017 This is the third in a series of articles reporting on a study of researcher data management practices and data services at the University of Vermont.
Elizabeth A. Berman
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Two-stage re-estimation adaptive design: a simulation study
Epidemiology, Biostatistics and Public Health, 2022 Background: adaptive clinical trial design has been proposed as a promising new approach to improve the drug discovery process. Among the many options available, adaptive sample size re-estimation is of great interest mainly because of its ...
Francesca Galli, Luigi Mariani
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Antipyretic therapy in critically ill patients with established sepsis: a trial sequential analysis.
PLoS ONE, 2015 Background and objectiveantipyretic therapy for patients with sepsis has long been debated. The present study aimed to explore the beneficial effect of antipyretic therapy for ICU patients with sepsis.Designsystematic review and trial sequential analysis
Zhongheng Zhang
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Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
BMC Medical Research MethodologyBackground Group sequential designs are increasingly employed to allow trials to stop early with statistical rigor. While existing work focuses on intention-to-treat effect on clinical endpoints, the properties of mediation analysis (commonly conducted ...
Kim May Lee, Richard Emsley
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Two-stage re-estimation adaptive design: a simulation study
Epidemiology, Biostatistics and Public Health, 2013 Background: adaptive clinical trial design has been proposed as a promising new approach to improve the drug discovery process. Among the many options available, adaptive sample size re-estimation is of great interest mainly because of its ability to ...
Francesca Galli, Luigi Mariani
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The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Discussion of Sequential quasi Monte Carlo
, 2015 International audienceThis is a written discussion of the paper "sequential quasi-Monte Carlo sampling" by M. Gerber and N. Chopin, following the presentation given before the Royal Statistical Society in London on December 10th ...
Prünster, Igor +2 more
core +1 more source
Ingeniería e Investigación, 2010 Metalworking companies represent one of the strategic sectors in the regional economy of the Caldas department in Colombia; in fact, this sector is involved in 31% of the department’s industrial establishments and 29% of industrial employment according ...
Jaime Alberto Giraldo García +2 more
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