Results 211 to 220 of about 12,245,503 (251)

Oral, intravenous, or sequential alpha-lipoic acid for diabetic peripheral neuropathy? A Bayesian network meta-analysis of randomized controlled trials. [PDF]

Front Neurol
Shen J, Zheng Y, Yu M, Wang X.
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Safety profile of elafibranor versus placebo in primary biliary cholangitis: A systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials. [PDF]

Medicine (Baltimore)
Khan NA, Shahbaz H, Talha M, Khan MA, Tahir MA, Anwar U, Khan MA, Adhikari P.   +7 more
europepmc   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

The specific nature of the statistical learning deficit in developmental dyslexia: Impaired temporal and spared spatial learning abilities. [PDF]

Psychon Bull Rev
Shukri AM, Growns B, Siegelman N, Gabay Y.   +3 more
europepmc   +1 more source

Social determinants of health and postnatal wellbeing among women with type 2 diabetes in Thailand: An explanatory sequential mixed-methods study protocol. [PDF]

PLoS One
Phonyiam R, Srichalerm T, Sawatpanich A, Keawpugdee J.   +3 more
europepmc   +1 more source

Use of Composite Priors for Assurance of Sequential Therapy Trials: Practical Experiences Using Binary Endpoint Data. [PDF]

Pharm Stat
Wright J, Ye L.
europepmc   +1 more source

Pre-Extubation Low-Dose Propofol in Pediatric Ear, Nose, and Throat Procedures: A Meta-Analysis With Trial Sequential Analysis. [PDF]

Paediatr Anaesth
Silva R, Mendes R, Borges JM, Pivetta H, Miranda R, Alles I, Oliveira V, Staffa S, Alrayashi W.   +8 more
europepmc   +1 more source