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Statistical inference problems in sequential parallel comparison design

Journal of Biopharmaceutical Statistics, 2019
The sequential parallel comparison designhas recently been considered to solve the problem with high placebo response and the required sample size in the psychiatric clinical trials. One feature with this design is that a difference between the placebo group and the drug group may also arise in the variance-covariance structure of the clinical outcome.
Yifan, Cui   +2 more
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Comparison of Test Statistics for the Sequential Parallel Design

Statistics in Biopharmaceutical Research, 2010
The sequential parallel design has been proposed to improve the efficiency of clinical trials in psychiatry. The design randomizes patients into three treatment groups. Each group has two phases. The three groups are (1) placebo in the first phase followed by placebo in the second phase, (2) placebo in the first phase followed by drug in the second ...
Xiaohong Huang, Roy N. Tamura
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Rejoinder to “Statistical inference problems in sequential parallel comparison designs”

Journal of Biopharmaceutical Statistics, 2019
In this rejoinder the authors stipulate further for two challenging issues. First, if placebo non-responders are selected simply by their response meeting a threshold, this selection may have misclassification error and consequently the treatment effect estimate may be biased, regardless of whether the estimand at the second stage is the treatment ...
Yifan, Cui   +2 more
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A commentary on: statistical inference problems in sequential parallel comparison designs

Journal of Biopharmaceutical Statistics, 2019
A Sequential Parallel Comparison Design has two stages, the first comparing drug to placebo and the second comparing drug to placebo among patients who did not respond to placebo in the first stage. The paper, Statistical Inference Problems in Sequential Parallel Comparison Designs, claims that the estimate of the treatment difference in the second ...
David Alan, Schoenfeld   +2 more
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Sequential statistical design strategy in an experimental kinetic study

The Canadian Journal of Chemical Engineering, 1972
AbstractThe value of using a sequential statistical design strategy is illustrated through its use in an experimental kinetic study of the oxidation of o‐xylene over a vanadium oxide catalyst. The rate of oxidation of o‐xylene was determined in a differential reactor over the following ranges of conditions: 270 to 300°C, (0.5 to 3.5) x 10‐4g.mole o ...
J. A. Juusola, D. W. Bacon, J. Downie
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Statistical Considerations and Software for Designing Sequential, Multiple Assignment, Randomized Trials (SMART) with a Survival Final Endpoint

Journal of Biopharmaceutical Statistics, 2023
Sequential, multiple assignment, randomized trial (SMART) designs are appropriate for comparing adaptive treatment interventions, in which intermediate outcomes (called tailoring variables) guide subsequent treatment decisions for individual patients. Within a SMART design, patients may be re-randomized to subsequent treatments following the outcomes ...
Sasha, Kravets   +4 more
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Statistical Design of Sequential Decision Making Algorithms

2022
Sequential decision-making is a fundamental class of problem that motivates algorithm designs of online machine learning and reinforcement learning. Arguably, the resulting online algorithms have supported modern online service industries for their data-driven real-time automated decision making.
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Sequential statistical design strategy in a kinetic study of propylene oxidation

The Canadian Journal of Chemical Engineering, 1989
AbstractA sequential design strategy was used to direct an experimental kinetic study of propylene oxidation over bismuth molybdate. Two statistical criteria were used to design experiments. The first is a joint criterion for the dual problem of model discrimination and parameter estimation which was proposed by Hill et al.
H. S. Tan, D. W. Bacon, J. Downie
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Optimization of fermentation media for nitrite oxidizing bacteria using sequential statistical design

Bioresource Technology, 2008
The sequential statistical experimental design (Plackett-Burman, factorial, response surface and steepest ascent experiment) was applied to optimize the culture medium of nitrite oxidizing bacteria for improving the nitrite oxidizing rate. Estimated optimum medium composition of the nitrite oxidizing rate was as follows: NaHCO3, 1.86gl(-1); NaNO2, 2 ...
Jie, Ren   +5 more
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Optimal Design of Reliability Acceptance Sampling Plan Based on Sequential Order Statistics

Stochastics and Quality Control, 2019
Abstract The concept of sequential order statistics were introduced by Kamps in 1995. In this article, we derive an acceptance sampling plan, for units having exponentially distributed lifetime, using sequential order statistics. Based on data obtained from progressive type II censoring using constant stress accelerated life tests, we ...
Kumar, Mahesh, Ramyamol, P. C.
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