Results 131 to 140 of about 5,820 (141)

Geographic differentiation of polymorphism in the Plasmodium falciparum malaria vaccine candidate gene SERA5

Vaccine, 2012
SERA5 is regarded as a promising malaria vaccine candidate of the most virulent human malaria parasite Plasmodium falciparum. SERA5 is a 120 kDa abundantly expressed blood-stage protein containing a papain-like protease. Since substantial polymorphism in blood-stage vaccine candidates may potentially limit their efficacy, it is imperative to fully ...
Nobuko Arisue, Nirianne Marie Palacpac, Takahiro Tougan   +2 more
exaly   +3 more sources

Structural Insights into the Protease-like Antigen Plasmodium falciparum SERA5 and Its Noncanonical Active-Site Serine

Journal of Molecular Biology, 2009
The sera genes of the malaria-causing parasite Plasmodium encode a family of unique proteins that are maximally expressed at the time of egress of parasites from infected red blood cells. These multi-domain proteins are unique, containing a central papain-like cysteine-protease fragment enclosed between the disulfide-linked N- and C-terminal domains ...
Oliver B Clarke, Walter D Fairlie, Peter M Colman   +2 more
exaly   +3 more sources

HIGH TITERS OF IgG ANTIBODIES AGAINST PLASMODIUM FALCIPARUM SERINE REPEAT ANTIGEN 5 (SERA5) ARE ASSOCIATED WITH PROTECTION AGAINST SEVERE MALARIA IN UGANDAN CHILDREN

American Journal of Tropical Medicine and Hygiene, 2006
Plasmodium falciparum serine repeat antigen (SERA5) is a promising asexual blood stage malaria candidate vaccine. However, there is a paucity of information about natural immune responses to SERA5 in children from malaria-endemic regions. We undertook a hospital-based case-control study of severe malaria in Apac District, Northern Uganda, in children 6–
Toshihiro Horii
exaly   +3 more sources

In silico approach to ascertain the calcium dependent role of Plasmodium falciparum SERA5

Journal of Biomolecular Structure and Dynamics, 2016
The P. falciparum serine repeat antigen (PfSERA5) is the most abundantly expressed protein in the parasitophorous vacuole during the asexual blood stage and serves as both drug and vaccine target. The processed central fragment (56 KDa) of PfSERA5 is implicated to play an important role in parasite exit (egress) during schizont rupture from ...
C N, Rahul, K, Shiva Krishna, Atul P, Pawar, Vidya, Rajesh   +3 more
openaire   +2 more sources

Faculty Opinions recommendation of Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2015
Toshihiro Horii, Nirianne Palacpac
openaire   +1 more source

Faculty Opinions recommendation of The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2017
Toshihiro Horii, Nirianne Palacpac
openaire   +1 more source

Assessment of Mixed Plasmodium falciparum sera5 Infection in Endemic Burkitt Lymphoma: A Case-Control Study in Malawi

Cancers, 2021
Nobuko Arisue, Nirianne Marie Palacpac, Nora Mutalima   +2 more
exaly  

Faculty Opinions recommendation of Synthetic peptides derived from the C-terminal 6kDa region of Plasmodium falciparum SERA5 inhibit the enzyme activity and malaria parasite development.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2014
Toshihiro Horii, Nirianne Palacpac
openaire   +1 more source

In silico approach to ascertain the calcium dependent role of Plasmodium falciparum SERA5

Journal of Biomolecular Structure and Dynamics, 2017
Vidya Rajesh
exaly  

Synthetic peptides derived from the C-terminal 6kDa region of Plasmodium falciparum SERA5 inhibit the enzyme activity and malaria parasite development

Biochimica Et Biophysica Acta - General Subjects, 2014
Sergio Romeo, Pawan Malhotra
exaly