Results 1 to 10 of about 10,338 (254)

RBFOX1 Regulates Calcium Signaling and Enhances SERCA2 Translation [PDF]

Cells
RBFOX1 is an RNA-binding protein that regulates alternative splicing and RNA processing in the neurons, skeletal muscle, and heart. We intended to define the role of RBFOX1 in regulating calcium homeostasis to maintain normal cardiac function.
Sadiq Umar, Wuqiang Zhu, Fernando Souza-Neto, Ingrid Bender, Steven C. Wu, Chastity L. Healy, Timothy D. O’Connell, Jop H. van Berlo   +7 more
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SERCA2 phosphorylation at serine 663 is a key regulator of Ca2+ homeostasis in heart diseases [PDF]

Nature Communications, 2023
Despite advances in cardioprotection, new therapeutic strategies capable of preventing ischemia-reperfusion injury of patients are still needed. Here, we discover that sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA2) phosphorylation at serine 663 ...
Fabrice Gonnot, Laura Boulogne, Camille Brun, Maya Dia, Yves Gouriou, Gabriel Bidaux, Christophe Chouabe, Claire Crola Da Silva, Sylvie Ducreux, Bruno Pillot, Andrea Kaczmarczyk, Christelle Leon, Stephanie Chanon, Coralie Perret, Franck Sciandra, Tanushri Dargar, Vincent Gache, Fadi Farhat, Laurent Sebbag, Thomas Bochaton, Helene Thibault, Michel Ovize, Melanie Paillard, Ludovic Gomez   +23 more
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Highly expressed SERCA2 triggers tumor cell autophagy and is a druggable vulnerability in triple-negative breast cancer

Acta Pharmaceutica Sinica B, 2022
Chemoresistance remains a major obstacle to successful treatment of triple negative breast cancer (TNBC). Identification of druggable vulnerabilities is an important aim for TNBC therapy.
Minmin Fan, Jian Gao, Lin Zhou, Wenwen Xue, Yixuan Wang, Jingwei Chen, Wuhao Li, Ying Yu, Bo Liu, Yan Shen, Qiang Xu   +10 more
doaj   +3 more sources

Pharmacological activation of SERCA2 reverses ER calcium dysregulation and depression-like behaviors in hyperglycemic mice [PDF]

Scientific Reports
Chronic hyperglycemia is linked to neuronal dysfunction and mood disorders, but the underlying molecular mechanisms remain unclear. In the present study, we examined the role of sarco/endoplasmic reticulum Ca²⁺-ATPase 2 (SERCA2) in depression-like ...
Huiju Lee, Yiseul Han, Ju-Yeon Song, Do Gyeong Kim, Heekyoung Chung, Sung Jun Jung, Hyeon Son   +6 more
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CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells

Clinical and Experimental Hypertension, 2023
Background and Purpose Substitution of Cys674 (C674) in the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) causes SERCA2 dysfunction which leads to activated inositol requiring enzyme 1 alpha (IRE1α) and spliced X-box binding protein 1 (XBP1s)
Weimin Yu, Qian Zhang, Yixiang Qiu, Hui Chen, Xiaoyang Huang, Li Xiao, Gang Xu, Siqi Li, Pingping Hu, Xiaoyong Tong   +9 more
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Far-infrared irradiation attenuates vessel contraction by activating SERCA2 through disruption of SERCA2 and PLN interaction. [PDF]

PLoS ONE
Vascular smooth muscle cells (VSMCs) plays an important role in maintaining vascular function by responding to various vasoactive stimuli within blood vessels. Far-infrared (FIR) rays has been shown to possess a variety of physiological effects including
Yun-Jin Hwang, So-Young Park, Jung-Hyun Park, Du-Hyong Cho   +3 more
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Sustained developmental endothelial locus-1 overexpression promotes spinal cord injury recovery in mice through the SIRT1/SERCA2 signaling pathway

Brain Research Bulletin, 2022
Although the anti-inflammatory properties of developmental endothelial locus-1 (DEL-1) are well known, few studies have examined the role of DEL-1 in spinal cord injury (SCI).
Ming Cheng, Hongxin Wang, Guang Yang, Yuanchi Cheng, Zhen Yang, Xuyi Chen, Yingfu Liu, Zhonglei Sun   +7 more
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The substitution of SERCA2 redox cysteine 674 promotes pulmonary vascular remodeling by activating IRE1α/XBP1s pathway

Acta Pharmaceutica Sinica B, 2022
Pulmonary hypertension (PH) is a life-threatening disease characterized by pulmonary vascular remodeling, in which hyperproliferation of pulmonary artery smooth muscle cells (PASMCs) plays an important role.
Weimin Yu, Gang Xu, Hui Chen, Li Xiao, Gang Liu, Pingping Hu, Siqi Li, Vivi Kasim, Chunyu Zeng, Xiaoyong Tong   +9 more
doaj   +3 more sources

Endoplasmic reticulum stress-related deficits in calcium clearance promote neuronal dysfunction that is prevented by SERCA2 gene augmentation [PDF]

Cell Reports Medicine
Summary: Disruption of calcium (Ca2+) homeostasis in neurons is a hallmark of neurodegenerative diseases. Here, we investigate the mechanisms leading to Ca2+ dysregulation and ask whether altered Ca2+ dynamics impinge on neuronal stress and circuit ...
Yukihiro Shiga, Aline Giselle Rangel Olguin, Sana El Hajji, Nicolas Belforte, Heberto Quintero, Florence Dotigny, Luis Alarcon-Martinez, Arjun Krishnaswamy, Adriana Di Polo   +8 more
doaj   +3 more sources

Translocation of IGF-1R in endoplasmic reticulum enhances SERCA2 activity to trigger Ca2+ER perturbation in hepatocellular carcinoma

Acta Pharmaceutica Sinica B, 2023
The well-known insulin-like growth factor 1 (IGF1)/IGF-1 receptor (IGF-1R) signaling pathway is overexpressed in many tumors, and is thus an attractive target for cancer treatment.
Yanan Li, Keqin Li, Ting Pan, Qiaobo Xie, Yuyao Cheng, Xinfeng Wu, Rui Xu, Xiaohui Liu, Li Liu, Jiangming Gao, Wenmin Yuan, Xianjun Qu, Shuxiang Cui   +12 more
doaj   +2 more sources