Results 91 to 100 of about 10,338 (254)

Nitric oxide stress and activation of AMP-activated protein kinase impair β-cell sarcoendoplasmic reticulum calcium ATPase 2b activity and protein stability [PDF]

, 2015
The sarcoendoplasmic reticulum Ca(2+) ATPase 2b (SERCA2b) pump maintains a steep Ca(2+) concentration gradient between the cytosol and ER lumen in the pancreatic β-cell, and the integrity of this gradient has a central role in regulated insulin ...
Evans-Molina, C., Kono, T., Tong, X.
core   +2 more sources

Myocardial SERCA2 Protects Against Cardiac Damage and Dysfunction Caused by Inhaled Bromine

Journal of Pharmacology and Experimental Therapeutics
Myocardial sarcoendoplasmic reticulum calcium ATPase 2 (SERCA2) activity is critical for heart function. We have demonstrated that inhaled halogen (chlorine or bromine) gases inactivate SERCA2, impair calcium homeostasis, increase proteolysis, and damage
J. M. Masjoan Juncos, Fahad Nadeem, S. Shakil, M. El-Husari, Iram Zafar, W. Louch, G. Halade, A. Zaky, A. Ahmad, Shama Ahmad   +9 more
semanticscholar   +1 more source

Human platelets express the SERCA2-b isoform of Ca2+-transport ATPase [PDF]

Biochemical Journal, 1992
Previous biochemical studies suggested that the human platelet Ca2+ATPase system may be cell-specific. To test this hypothesis, we first undertook the molecular cloning of Ca2+ATPase from human erythroleukaemia (HEL) cells, because this human cell line exhibits megakaryocytic features and expresses a Ca2+ATPase that cross-reacts with platelet Ca(2 ...
J, Enouf, R, Bredoux, B, Papp, I, Djaffar, A M, Lompré, N, Kieffer, O, Gayet, K, Clemetson, F, Wuytack, J P, Rosa   +9 more
openaire   +2 more sources

Moderate Modulation of Cardiac PGC-1α Expression Partially Affects Age-Associated Transcriptional Remodeling of the Heart [PDF]

, 2018
Aging is associated with a decline in cardiac function due to a decreased myocardial reserve. This adverse cardiac remodeling comprises of a variety of changes, including a reduction in mitochondrial function and a decline in the expression of the ...
Brink, Marijke, Gill, Jonathan F., Handschin, Christoph, Whitehead, Natasha   +3 more
core   +2 more sources

CARBONYLATION CONTRIBUTES TO SERCA2 ACTIVITY LOSS DURING DIABETES

The FASEB Journal, 2009
The present study was undertaken to determine if carbonylation of SERCA2 contributes to the prolongation of active cardiac relaxation time during diabetes. Type 1 diabetes was induced in male Sprague‐Dawley rats using streptozotocin (STZ).
ChunHong Shao, Haley L Capek, Kaushik Patel, Ryoji Nagai, Seikoh Horiuchi, Keshore R Bidasee   +5 more
openaire   +1 more source

Sarcoplasmic Reticulum-Independent Contractile Function in Serca2 Ablated Hearts [PDF]

Biophysical Journal, 2014
Effective contraction and relaxation of the heart requires the robust transport of Ca2+ to and from the sarcoplasmic reticulum (SR). The cardiac SR Ca-ATPase, SERCA2a, is responsible for sequestering Ca2+ to the SR during the contractile cycle, and has diminished expression and function in failing hearts.
Heinis, Frazer I., Metzger, Joseph M.
openaire   +1 more source

Transcriptomic Remodeling of Pulmonary Vein Sleeves Suggests a Role in Atrial Arrhythmogenesis in Thoroughbred Horses

Annals of the New York Academy of Sciences, EarlyView.
Myocardial sleeves of the pulmonary veins in racehorses with paroxysmal atrial fibrillation exhibit upregulated pathways associated with tissue structure remodeling. Pathways related to the extracellular matrix and cellular components differ significantly from those in healthy horses.
Magdalena Arevalo‐Turrubiarte, Charlotte E. Edling, Carla Moller‐Levet, Bronte Forbes, Victoria Kemp, Joe Weir, Celia Marr, Rebecca Lewis, Kamalan Jeevaratnam   +8 more
wiley   +1 more source

Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes. [PDF]

, 2013
Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) provide a promising source for cell therapy and drug screening. Several high-yield protocols exist for hESC-CM production; however, methods to significantly advance hESC-CM maturation are still ...
Bursac, N, Lam, J, Shadrin, IY, Snodgrass, HR, Xian, HQ, Zhang, D   +5 more
core   +1 more source

Modulation of SERCA2 activity: Regulated splicing and interaction with phospholamban

Bioscience Reports, 1995
Ca2+-uptake into intracellular stores is mediated by the sarco/endoplasmic reticulum Ca2+ATPases (SERCAs). This review deals first with the gene structural and the characterization of the tissue-specific SERCA2 transcript processing. Secondly, the two different protein isoforms and their regulation are described.
H, Verboomen, L, Mertens, J, Eggermont, F, Wuytack, L, Van Den Bosch   +4 more
openaire   +2 more sources

Antenatal betamethasone impairs markers of cardiac development and function in near‐term lambs

Experimental Physiology, EarlyView.
Abstract figure Summary of key molecular differences in the left ventricle of near‐term lambs exposed to antenatal betamethasone, compared to saline. Pregnant ewes received two doses of either saline (Saline) or betamethasone (Betamethasone, intramuscular, 11.4 mg) given 24 h apart, before delivery at 140 days of gestation (dG, term = 150 dG).
Reza Amanollahi, Ashley S. Meakin, Stacey L. Holman, Vicki L. Clifton, Kent L. Thornburg, Michael D. Wiese, Kathryn L. Gatford, Mitchell C. Lock, Janna L. Morrison   +8 more
wiley   +1 more source