The Journal of Physiology, EarlyView.Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise +2 more
wiley +1 more source
Adenovirus-based phospholamban antisense expression as a novel approach to improve cardiac contractile dysfunction: comparison of a constitutive viral versus an endothelin-1-responsive cardiac promoter [PDF]
, 2000 BACKGROUND: A decrease in sarcoplasmic reticulum Ca(2+) pump (SERCA2) activity is believed to play a role in the impairment of diastolic function of the failing heart.
Bezstarosti, K. (Karel) +8 more
core +2 more sources
Cell Biochemistry and Function, Volume 44, Issue 2, February 2026.ABSTRACT Living beings are persistently challenged by stress. Stress can be induced by internal stressors and external stressors. External stressors, including radiation, heat, heavy metals, nutritional imbalances, infections, and psychological stress, can induce protein denaturation, leading to misfolded or aggregated proteins.
Paka Sravan Kumar +5 more
wiley +1 more source
Multiple Ca2+ signaling pathways regulate intracellular Ca 2+ activity in human cardiac fibroblasts [PDF]
, 2010 Ca2+ signaling pathways are well studied in cardiac myocytes, but not in cardiac fibroblasts. The aim of the present study is to characterize Ca2+ signaling pathways in cultured human cardiac fibroblasts using confocal scanning microscope and RT-PCR ...
Chen, JB +5 more
core +1 more source
Increased activation of ErbB and NFκB signalling pathways in Darier disease affected skin
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Nancy Ernst +2 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.BETMB exerts multi‐target effects by positively modulating GABAARs and blocking NaV channels in a state‐dependent manner. This suppresses neuronal hyperexcitability, leading to seizure control and restoration of cognitive function. ABSTRACT Aims This study aims to evaluate 5‐(but‐1‐en‐1‐yl)‐1,2,3‐trimethoxybenzene (BETMB) as a novel dual‐target anti ...
Di Zhang +7 more
wiley +1 more source
The Effect of Aging on Calcium Transients in Rat Cardiomyocytes: Impact of NOX Inhibition [PDF]
, 2014 Contents: Iowa State experts\u27 analysis helps Groschopp improve products, satisfy customers; Iowa manufacturers should watch reshoring numbers closely, CIRAS research finds; CIRAS prompts $3.4M economic impact by helping Ryko Solutions build better ...
Gonzalez, Daniel R. +1 more
core +3 more sources
Transient receptor potential channel 1 deficiency impairs host defense and proinflammatory responses to bacterial infection by regulating protein kinase Cα signaling [PDF]
, 2015 Transient receptor potential channel 1 (TRPC1) is a nonselective cation channel that is required for Ca2+ homeostasis necessary for cellular functions. However, whether TRPC1 is involved in infectious disease remains unknown.
Birnbaumer, Lutz +12 more
core +1 more source
JNK2, A Newly-Identified SERCA2 Enhancer, Augments an Arrhythmic [Ca2+]SR Leak-Load Relationship.
Circulation Research, 2020 Rationale: We recently discovered pivotal contributions of stress kinase JNK2 in increased risk of atrial fibrillation (AF) through enhanced diastolic sarcoplasmic reticulum (SR) Ca2+ leak via ryanodine receptors (RyR2).
Jiajie Yan +11 more
semanticscholar +1 more source
Changes of SERCA activity have only modest effects on sarcoplasmic reticulum Ca2+ content in rat ventricular myocytes [PDF]
, 2011 : Changes of the activity of the sarco-endoplasmic reticulum Ca(2+)-ATPase (SERCA) affect the amplitude of the systolic Ca(2+) transient and thence cardiac contractility. This is thought to be due to alterations of SR Ca(2+) content.
Bode, EF +5 more
core +1 more source