Results 121 to 130 of about 10,338 (254)

Piezo1 in intestinal smooth muscle cells: Emerging perspectives

The Journal of Physiology, Volume 604, Issue 1, Page 129-144, 1 January 2026.
Abstract figure legend Loss of Piezo1 in SMCs results in delayed gut transit, impaired small bowel contractility, and tissue alterations. But more critically, Piezo1 is shown to be intracellularly localized, highlighting important implications given the phenotype. Adapted from Bautista, G.M. et al.
Geoanna M. Bautista, L. Fernando Santana, Martin G. Martin   +2 more
wiley   +1 more source

Modulation of endoplasmic reticulum calcium pump expression during lung cancer cell differentiation [PDF]

, 2012
Cellular calcium signaling plays important roles in several signal transduction pathways that control proliferation, differentiation and apoptosis. In epithelial cells calcium signaling is initiated mainly by calcium release from endoplasmic reticulum ...
Alexopoulou, Apáti, Arbabian, Berridge, Berridge, Bobe, Bobe, Brini, Brouland, Burdakov, Bánhegyi, Chandrasekera, Chang, Chang, Coe, Dally, Dellis, Diederichs, Dode, Foster, Gill, Gélébart, Hadri, Hakii, Hovnanian, Ivics, Ivics, Izsvák, Izsvák, Korošec, Korošec, Korošec, Lai, Launay, Launay, Launay, Lipskaia, Liu, Loffing, Lytton, Malhotra, Mates, Mathia, Nakai, Orbán, Papp, Papp, Papp, Papp, Poch, Prasad, Sakai, Travis, Vandecaetsbeek, Vangheluwe, Váradi, Wuytack, Wuytack, Wuytack, Youlden   +59 more
core   +1 more source

Role of the JP45-Calsequestrin Complex on Calcium Entry in Slow Twitch Skeletal Muscles [PDF]

, 2016
We exploited a variety of mouse models to assess the roles of JP45-CASQ1 (CASQ, calsequestrin) and JP45-CASQ2 on calcium entry in slow twitch muscles.
Bergamelli, Leda, Bongianino, Rossana, De Negri, Marco, Eckhardt, Jan, Mosca, Barbara, Priori, Silvia G., Protasi, Feliciano, Treves, Susan, Zorzato, Francesco   +8 more
core   +1 more source

THE M-RNA, EXPRESSION OF SERCA2 AND NCX1 IN THE PROCESS OF PHARMACOLOGICAL CELL PROTECTION IN EXPERIMENTAL ACUTE PANCREATITIS INDUCED BY TAUROCHOLATE

, 2022
Ênio R. Vasques, José Eduardo Monteiro CUNHA, Márcia Saldanha Kubrusly, Ana Coelho, Sandra N. SANPIETRI, Helena B. Nader, Ivarne L.S. Tersariol, Marcelo A. Lima, Eleazar Chaib, Luiz Augusto Carneiro D’Albuquerque   +9 more
openalex   +1 more source

糖尿病の骨格筋における　in vivoカルシウム調節機構 [PDF]

, 2016
The morphological and functional property in the skeletal muscle is associated with intracellular Ca2+([Ca2+]i)homeostasis. In this thesis,[Ca2+]i homeostatic control mechanism was investigated by in vivo bioimaging on animal model of diabetes mellitus ...
Hiroaki Eshima, 江島 弘晃
core   +2 more sources

Mesenchymal stromal cells inhibit NLRP3 inflammasome activation in a model of Coxsackievirus B3-induced inflammatory cardiomyopathy [PDF]

, 2018
Inflammation in myocarditis induces cardiac injury and triggers disease progression to heart failure. NLRP3 inflammasome activation is a newly identified amplifying step in the pathogenesis of myocarditis.
A Abbate, A Abbate, A Sabbah, AL Caforio, BJ Pomerantz, BW Tassell Van, C Badorff, C Tschope, CA Janeway Jr., CF McTiernan, DA Neumann, E Kiss, E Mezzaroma, F Coulombe, F Escher, F Martinon, FS Sutterwala, J Yang, JH Fritz, JY Oh, K Li, K Miteva, K Savvatis, KM Davis, L Andreoletti, L Liu, M Kasner, M Kawaguchi, M Lech, N Neu, N Neu, O Hofnagel, PJ Shaw, PM Ridker, S Linthout Van, S Ong, S Toldo, T Binger, U Eriksson, U Kuhl, U Kuhl, X Li, X Si, Y Wang   +43 more
core   +1 more source

Changes in cardiac phenotype in hypertrophy and failure: From receptor to gene [PDF]

, 1997
The terminally differentiated adult cardiac myocyte cannot undergo cellular division. Growth of the heart in response to chronic hemodynamic overload therefore occurs through hypertrophy of the myocytes.
Heugten, H.A. (Han) van, Lamers, J.M.J. (Jos)   +1 more
core   +3 more sources

Axial tubule junctions control rapid calcium signaling in atria. [PDF]

, 2016
The canonical atrial myocyte (AM) is characterized by sparse transverse tubule (TT) invaginations and slow intracellular Ca2+ propagation but exhibits rapid contractile activation that is susceptible to loss of function during hypertrophic remodeling ...
Agarwal, Arakel, Brandenburg, Christopher W. Ward, Elke Hebisch, Eva A. Rog-Zielinska, Eva Wagner, George S.B. Williams, Gerd Hasenfuss, Hüser, Kirk, Konstantin Gusev, Mackenzie, Michael Didié, Michael Gotthardt, Miroslav Dura, Nabauer, Peter Kohl, Stephan E. Lehnart, Sören Brandenburg, Tobias Kohl, Viacheslav O. Nikolaev, Voigt, W. Jonathan Lederer, Wagner, Woo, Xie   +26 more
core   +1 more source

Effects of human recombinant growth hormone on exercise capacity, cardiac structure, and cardiac function in patients with adult-onset growth hormone deficiency [PDF]

, 2017
Objective Epidemiological studies suggest that adult-onset growth hormone deficiency (AGHD) might increase the risk of death from cardiovascular causes. Methods This was a 6-month double-blind, placebo-controlled, randomised, cross-over trial followed by
Atkin, S. L., Atkin, Stephen, Clark, AL, Clark, Andrew, Gonzalez, S., Gonzalez, Susana, Javed, Z., Javed, Zeeshan, Sathyapalan, T., Sathyapalan, Thozhukat, Windram, Hull, Windram, J. D.   +11 more
core   +1 more source

Theaflavin-3,3'-digallate alleviates glucolipotoxicity-induced insulin secretion dysfunction in pancreatic β-TC-6 cells and zebrafish via anti-ferroptotic mechanisms by activating SERCA2

Food Science and Human Wellness
Theaflavins from black tea effectively improve insulin secretion in obesity and diabetes, but the molecular mechanisms are unclear. Here, the palmitic acid (PA)-induced pancreatic β-TC-6 cells and high fat-/high glucose-induced zebrafish were used.
Kaixi Wang, Huanqing Zhu, Jiaxin Kang, Shuna Chen, Puming He, Youying Tu, Bo Li   +6 more
doaj   +1 more source