Experimental Physiology, 2018 New Findings What is the central question of this study? Does Toll‐like receptor 7 (TLR7) have any direct effects on Ca2+‐dependent physiological function of tracheal submucosal gland cells? What is the main finding and its importance?
Shunichi Gamo +9 more
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The Scientific World Journal, 2002 The sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs) belong to a family of active calcium transport enzymes encoded by the SERCA1, 2, and 3 genes. In this study, we describe the complete structure of the human SERCA2 gene and its 5’ -regulatory region.
Angel Zarain-Herzberg +1 more
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Sp1 and Sp3 transcription factors are required for trans-activation of the human SERCA2 promoter in cardiomyocytes [PDF]
, 2003 Mariea A. Brady
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SELENOT regulates endoplasmic reticulum calcium flux via SERCA2 and maintains dopaminergic DAT to protect against attention deficit hyperactivity disorder in mice [PDF]
, 2023 Qing Guo +9 more
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DP71 and SERCA2 alteration in human neurons of a Duchenne muscular dystrophy patient
Stem Cell Research & Therapy, 2019 Cognitive deficit has been identified in one third of patients affected by Duchenne Muscular Dystrophy, primarily attributed to loss of the short Dp71 dystrophin, the major brain dystrophin isoform.
Simona Ruggieri +16 more
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Keratinizációs zavarok ultrastrukturális és genetikai vizsgálata = Ultrastructural and Genetic Studies in Disorders of Cornification [PDF]
, 2007 Az elmúlt három évben megteremtettük hazánkban a legsúlyosabb örökletes bőrgyógyászati kórképek közt egyes keratinizációs zavarok (pl. társult ichthyosisok, dyskeratosis follicularis) ultrastrukturális és genetikai vizsgálatainak alapjait, lehetővé téve ...
Becker, Krisztina +3 more
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321 A human tissue model of Darier disease reveals MEK as a novel therapeutic target downstream of SERCA2 deficiency [PDF]
, 2023 S.A. Zaver +7 more
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Conditional SERCA2 Ablation Impairs Systolic and Diastolic Performance of Isolated Perfused Hearts [PDF]
, 2012 Frazer I. Heinis +3 more
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Dantrolene corrects cellular disease features of Darier disease and may be a novel treatment
EMBO Molecular MedicineDarier disease (DD) is a rare severe acantholytic skin disease caused by mutations in the ATP2A2 gene that encodes for the sarco/endoplasmic reticulum calcium ATPase isoform 2 (SERCA2).
Matthew Hunt +16 more
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